Porous carriers for biomedical applications based on alginate hydrogels

被引：286

作者：

Eiselt, P

Yeh, J

Latvala, RK

Shea, LD

Mooney, DJ

机构：

[1] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

来源：

BIOMATERIALS | 2000年 / 21卷 / 19期

关键词：

alginate; gas-foaming process; porous beads; scaffolds;

D O I：

10.1016/S0142-9612(00)00033-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Macroporous scaffolds are typically utilized in tissue engineering applications to allow for the migration of cells throughout the scaffold and integration of the engineered tissue with the surrounding host tissue. A method to form macroporous beads with an interconnected pore structure from alginate has been developed by incorporating gas pockets within alginate beads, stabilizing the gas bubbles with surfactants, and subsequently removing the gas. Macroporous scaffolds could be formed from alginate with different average molecular weights (5-200 kDa) and various surfactants. The gross morphology, amount of interconnected pores, and total void volume was investigated both qualitatively and quantitatively. Importantly, macroporous alginate beads supported cell invasion in vitro and in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1921 / 1927

页数：7

共 18 条

[1] MICELLIZATION OF POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) TRIBLOCK COPOLYMERS IN AQUEOUS-SOLUTIONS - THERMODYNAMICS OF COPOLYMER ASSOCIATION [J].