Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase

被引：43

作者：

Koketsu, M

Choi, SY

Ishihara, H

Lim, BO

Kim, H

Kim, SY ^{[1
]}

机构：

[1] Kyung Hee Univ, Grad Sch East West Med Sci, Seoul 130701, South Korea

[2] Gifu Univ, Fac Engn, Dept Chem, Gifu 5011193, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 12期

关键词：

1,3-selenazol-4-one; tyrosinase; whitening agent;

D O I：

10.1248/cpb.50.1594

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study reports depigmenting potency of 1,3-selenazol-4-one derivatives, which would be based upon the finding of direct inhibition to mushroom tyrosinase. 1,3-Selenazol-4-one derivatives exhibited inhibitory effect on dopa oxidase activity of mushroom tyrosinase. In this study, inhibitory effects of six kinds of 1,3-selenazol-4-one derivatives (A, B, C, D, E and F) on mushroom tyrosinase were investigated. Compounds at a concentration of 500 mum exhibited 33.4-62.1% of inhibition on dopa oxidase activity of mushroom tyrosinase. Their inhibitory effects were higher than that of kojic acid (31.7%), a well known tyrosinase inhibitor. 2-(4-Methylphenyl)-1,3-selenazol-4-one (A) exhibited the strongest inhibitory effect among them dose-dependently and in competitive inhibition manner.

引用

页码：1594 / 1596

页数：3

共 11 条

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[2]

Bronzetti Giorgio, 1996, Journal of Environmental Pathology Toxicology and Oncology, V15, P59

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