CONVENIENT ONE-POT SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW MANNICH BASES OF 5-NITRO-2-FURFURALDEHYDE SEMICARBAZONE

被引：0

作者：

Joshi, Sh. ^{[1
]}

Manikpuri, A. D. ^{[1
]}

Tiwari, Prapti ^{[1
]}

Khadikar, P. V. ^{[2
]}

机构：

[1] Devi Ahilya Univ, Sch Chem Sci, Indore 452001, Madhya Pradesh, India

[2] Laxmi Fumigat & Pest Control, Indore, Madhya Pradesh, India

来源：

OXIDATION COMMUNICATIONS | 2010年 / 33卷 / 02期

关键词：

5-nitro-2-furfuraldehyde semicarbazone; sulphonamides; the Mannich bases; antimicrobial activity; toxicity; statistical analysis; DERIVATIVES; AGENT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of the Mannich bases of 5-nitro-2-furfuraldehyde semicarbazone with sulphonamides (3a-3e) has been synthesised and evaluated as antimicrobial agents. Structures of all the newly formed compounds were established on the basis of elemental analysis and spectroscopic data (UV, IR and (1)H NMR). All compounds proved to have great potentialities as excellent antibacterial agents and were found to be low lethal as ascertained by LD(50) test. The results obtained are compared with those obtained for the parent sulphonamides.

引用

页码：398 / 407

页数：10

共 17 条

[1] Antioxidant and antiproliferative activity of curcumin semicarbazone [J].

Dutta, S ;

Padhye, S ;

Priyadarsini, KI ;

Newton, C .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (11) :2738-2744

[2] In vitro study of some medicinally important Mannich bases derived from antitubercular agent [J].

Joshi, S ;

Khosla, N ;

Tiwari, P .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (03) :571-576

[3] Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide [J].

Joshi, Sheela ;

Das Manikpuri, Anju ;

Tiwari, Prapti .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (03) :645-648

[4]

Joshi Sheela, 2002, Acta Pharmaceutica (Zagreb), V52, P197

[5]

Khosla Navita, 1998, Acta Pharmaceutica (Zagreb), V48, P55

[6]

LENDNICER D, 1980, ORGANIC CHEM DRUG SY, V2

[7] ASSAY OF STREPTOMYCIN BY THE PAPER-DISC PLATE METHOD [J].

LOO, YH ;

SKELL, PS ;

THORNBERRY, HH ;

EHRLICH, J ;

MCGUIRE, JM ;

SAVAGE, GM ;

SYLVESTER, JC .

JOURNAL OF BACTERIOLOGY, 1945, 50 (06) :701-709

[8] QSAR study on the antibacterial activity of some sulfa drugs: building blockers of Mannich bases [J].

Mandloi, D ;

Joshi, S ;

Khadikar, PV ;

Khosla, N .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (02) :405-411

[9] ANTIMALARIAL ACTIVITY OF SULPHONAMIDES AND A SULPHONE SINGLY AND IN COMBINATION WITH PYRIMETHAMINE AGAINST DRUG RESISTANT AND NORMAL STRAINS OF LABORATORY PLASMODIA [J].

RICHARDS, WH .

NATURE, 1966, 212 (5069) :1494-+

[10] Mannich base: a cost effective, low temperature curing agent for epoxides [J].

Shukla, V. ;

Bajpai, M. ;

Habib, F. .

PIGMENT & RESIN TECHNOLOGY, 2007, 36 (03) :169-171

← 1 2 →