The roles of microphthalmia-associated transcription factor and pigmentation in melanoma

被引：107

作者：

Hsiao, Jennifer J.

Fisher, David E. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cutaneous Biol Res Ctr,Dept Dermatol, Charlestown, MA 02129 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 563卷

关键词：

MITF; Melanoma; Melanocyte; Pigmentation; CELL-CYCLE ARREST; LINEAGE SURVIVAL; BRAF MUTATIONS; B-RAF; MITF; TARGET; EXPRESSION; SENESCENCE; ONCOGENE; PROLIFERATION;

D O I：

10.1016/j.abb.2014.07.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：28 / 34

页数：7

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