Preparation of Folic Conjugated Magnetic Silica Mesoporous Nanoparticles and Their Encapsulated 10-HCPT Anticancer Behavior

被引：1

作者：

Hao, Bei-bei ^{[1
]}

Deng, Xiu-zhen ^{[1
]}

Yang, Jia-ke ^{[1
]}

Jia, Ying-dong ^{[1
]}

Shang, Xiao-jun ^{[1
]}

Shi, Yong-li ^{[1
]}

Yan, Xi-qing ^{[1
]}

机构：

[1] Xinxiang Med Univ, Coll Pharm, Xinxiang 453003, Henan, Peoples R China

来源：

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2022年 / 32卷 / 08期

关键词：

Mesoporous; Drug delivery; Magnetic; DRUG-DELIVERY; FOLATE RECEPTOR; 10-HYDROXYCAMPTOTHECIN; FLUORESCENCE; ACID;

D O I：

10.1007/s10904-022-02338-5

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel folate-decorated and magnetic mediated drug delivery system was fabricated by combining folate and magnetic nanoparticles to the surface of silica mesoporous nanoparticles (FMMSNs) via chemical reaction. The 10-hydroxycamptothecin (10-HPCT), an analogue of camptothecin, was sealed in the mesoporous to evaluate the system's pharmaceutics performance. The diameter of the FMMSMs was about 100 nm and the in vitro release result showed that the applied magnetic field could influence the release process. The result of the inhibition rate of the 10-HPCT loaded FMMSNs to HepG-2 cells revealed that they could be influenced by the applied magnetic field or the folic acid bonded on the surface of the mesoporous nanoparticles.

引用

页码：2986 / 2993

页数：8

共 50 条

[21] Preparation of rutin-loaded mesoporous silica nanoparticles and evaluation of its physicochemical, anticancer, and antibacterial properties
Memar, Mohammad Yousef
Abdolahinia, Elaheh Dalir
Yekani, Mina
Kouhsoltani, Maryam
Sharifi, Simin
Dizaj, Solmaz Maleki
MOLECULAR BIOLOGY REPORTS, 2023, 50 (01) : 203 - 213
[22] Preparation of rutin-loaded mesoporous silica nanoparticles and evaluation of its physicochemical, anticancer, and antibacterial properties
Mohammad Yousef Memar
Elaheh Dalir Abdolahinia
Mina Yekani
Maryam Kouhsoltani
Simin Sharifi
Solmaz Maleki Dizaj
Molecular Biology Reports, 2023, 50 : 203 - 213
[23] Preparation of magnetic mesoporous silica nanoparticles as a multifunctional platform for potential drug delivery and hyperthermia
Yu, Xia
Zhu, Yufang
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2016, 17 (01) : 229 - 238
[24] Paclitaxel/gelatin coated magnetic mesoporous silica nanoparticles: Preparation and antitumor efficacy in vivo
Che, Erxi
Gao, Yikun
Wan, Long
Zhang, Ying
Han, Ning
Bai, Junling
Li, Jia
Sha, Zhou
Wang, Siling
MICROPOROUS AND MESOPOROUS MATERIALS, 2015, 204 : 226 - 234
[25] Preparation of folic acid-conjugated dendritic mesoporous silica nanoparticles for pH-controlled release and targeted delivery of a cyclometallated gold(III) complex as an antitumor agent
Malekmohammadi, Samira
Hadadzadeh, Hassan
Amirghofran, Zahra
JOURNAL OF MOLECULAR LIQUIDS, 2018, 265 : 797 - 806
[26] Tuning the Release of Anticancer Drugs from Magnetic Iron Oxide/Mesoporous Silica Core/Shell Nanoparticles
Knezevic, Nikola Z.
Slowing, Igor I.
Lin, Victor S-Y.
CHEMPLUSCHEM, 2012, 77 (01): : 48 - 55
[27] An organosilane route to mesoporous silica nanoparticles with tunable particle and pore sizes and their anticancer drug delivery behavior
Zhao, Wenru
Zhang, Hongti
Chang, Shu
Gu, Jinlou
Li, Yongsheng
Li, Liang
Shi, Jianlin
RSC ADVANCES, 2012, 2 (12) : 5105 - 5107
[28] Preparation of magnetic nanoparticles encapsulated by an ultrathin silica shell via transformation of magnetic Fe-MCM-41
Arruebo, Manuel
Ho, Wing Yan
Lam, Koon Fung
Chen, Xinqin G.
Arbiol, Jordi
Santamaria, Jesus
Yeung, King Lun
CHEMISTRY OF MATERIALS, 2008, 20 (02) : 486 - 493
[29] Preparation and magnetic behavior of carbon-encapsulated cobalt and nickel nanoparticles from starch
Yu, C.
Qiu, J. S.
CHEMICAL ENGINEERING RESEARCH & DESIGN, 2008, 86 (8A): : 904 - 908
[30] Evaluating biological activity of folic acid-modified and 10-hydroxycamp-tothecin-loaded mesoporous silica nanoparticles
Ren, Bin
Chen, Di-Feng
Zhao, Xue-Jie
Li, Lin-Song
Zhao, Mei-Xia
MATERIALS CHEMISTRY AND PHYSICS, 2022, 292

← 1 2 3 4 5 →