Preparation of Folic Conjugated Magnetic Silica Mesoporous Nanoparticles and Their Encapsulated 10-HCPT Anticancer Behavior

被引：1
|
作者：
Hao, Bei-bei [1 ]
Deng, Xiu-zhen [1 ]
Yang, Jia-ke [1 ]
Jia, Ying-dong [1 ]
Shang, Xiao-jun [1 ]
Shi, Yong-li [1 ]
Yan, Xi-qing [1 ]
机构：
[1] Xinxiang Med Univ, Coll Pharm, Xinxiang 453003, Henan, Peoples R China
来源：
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2022年 / 32卷 / 08期
关键词：
Mesoporous; Drug delivery; Magnetic; DRUG-DELIVERY; FOLATE RECEPTOR; 10-HYDROXYCAMPTOTHECIN; FLUORESCENCE; ACID;
D O I：
10.1007/s10904-022-02338-5
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel folate-decorated and magnetic mediated drug delivery system was fabricated by combining folate and magnetic nanoparticles to the surface of silica mesoporous nanoparticles (FMMSNs) via chemical reaction. The 10-hydroxycamptothecin (10-HPCT), an analogue of camptothecin, was sealed in the mesoporous to evaluate the system's pharmaceutics performance. The diameter of the FMMSMs was about 100 nm and the in vitro release result showed that the applied magnetic field could influence the release process. The result of the inhibition rate of the 10-HPCT loaded FMMSNs to HepG-2 cells revealed that they could be influenced by the applied magnetic field or the folic acid bonded on the surface of the mesoporous nanoparticles.
引用
收藏
页码：2986 / 2993
页数：8
相关论文
共 50 条
  • [1] Preparation of Folic Conjugated Magnetic Silica Mesoporous Nanoparticles and Their Encapsulated 10-HCPT Anticancer Behavior
    Bei-bei Hao
    Xiu-zhen Deng
    Jia-ke Yang
    Ying-dong Jia
    Xiao-jun Shang
    Yong-li Shi
    Xi-qing Yan
    Journal of Inorganic and Organometallic Polymers and Materials, 2022, 32 : 2986 - 2993
  • [2] Preparation and characterization of CuO nanoparticles encapsulated in mesoporous Silica
    Wang, Peiyu
    Zheng, Xiaoping
    Wu, Xueyong
    Wei, Xiufang
    Zhou, Ling
    MICROPOROUS AND MESOPOROUS MATERIALS, 2012, 149 (01) : 181 - 185
  • [3] Folic acid-conjugated magnetic mesoporous silica nanoparticles loaded with quercetin: a theranostic approach for cancer management
    Mishra, Snehasis
    Manna, Krishnendu
    Kayal, Utpal
    Saha, Moumita
    Chatterjee, Sauvik
    Chandra, Debraj
    Hara, Michikazu
    Datta, Sriparna
    Bhaumik, Asim
    Das Saha, Krishna
    RSC ADVANCES, 2020, 10 (39) : 23148 - 23164
  • [4] Preparation, characterizations, and catalytic characteristics of Pd nanoparticles encapsulated in mesoporous silica
    Wang, Peiyu
    Wang, Zhongying
    Li, Jiangong
    Bai, Yongxiao
    MICROPOROUS AND MESOPOROUS MATERIALS, 2008, 116 (1-3) : 400 - 405
  • [5] Preparation and characterization of magnetic iron nanoparticles encapsulated in mesoporous silica: The effects of reduction procedure and pore size
    Wang, Nan-Nan
    Zeng, Shuang-Qin
    Guan, Xin
    Wang, Yong
    Cheng, Hai-Feng
    Wu, Wei-Zu
    MATERIALS LETTERS, 2013, 112 : 20 - 22
  • [6] Detection of TNT based on conjugated polymer encapsulated in mesoporous silica nanoparticles through FRET
    Feng, Lijuan
    Li, Hui
    Qu, Ying
    Lu, Changli
    CHEMICAL COMMUNICATIONS, 2012, 48 (38) : 4633 - 4635
  • [7] Preparation of melamine-functionalized mesoporous silica nanoparticles for delivery of anticancer drugs
    Mohan, Anandhu
    Ashwini, Munusamy
    Santhamoorthy, Madhappan
    Mani, Kailasam Saravana
    Pham, Thi Hong Trang
    Phan, Thi Tuong Vy
    Thirupathi, Kokila
    Sebastiammal, Saleth
    Lin, Mei-Ching
    Kumarasamy, Keerthika
    Pakiyaraj, Kanakaraj
    MATERIALS LETTERS, 2024, 371
  • [8] Preparation, characterization and in vitro anticancer activity of paclitaxel conjugated magnetic nanoparticles
    Tarantash, Mahsa
    Nosrati, Flamed
    Manjili, Hamidreza Kheiri
    Khoshfetrat, Ali Baradar
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2018, 44 (11) : 1895 - 1903
  • [9] Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers
    Qu, Wei
    Meng, Bo
    Yu, Yangyang
    Wang, Shaowei
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 : 4379 - 4389
  • [10] Platinum nanoparticles encapsulated in mesoporous silica:: Preparation, characterisation and catalytic activity in toluene hydrogenation
    Chytil, S
    Glomm, WR
    Vollebekk, E
    Bergem, H
    Walmsley, J
    Sjöblom, J
    Blekkan, EA
    MICROPOROUS AND MESOPOROUS MATERIALS, 2005, 86 (1-3) : 198 - 206
12345