Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival

被引：25
作者：
Rawat, Divya [1 ]
Chhonker, Saurabh Kumar [1 ]
Naik, Rayees Ahmad [2 ]
Mehrotra, Aditi [3 ]
Trigun, Surendra Kumar [3 ]
Koiri, Raj Kumar [1 ]
机构：
[1] Dr Harisingh Gour Cent Univ, Sch Biol Sci, Dept Zool, Biochem Lab, Sagar 470003, Madhya Pradesh, India
[2] Dr Harisingh Gour Cent Univ, Insect Immun Lab, Dept Zool, Sch Biol Sci, Sagar 470003, MP, India
[3] Banaras Hindu Univ, Dept Zool, Biochem & Mol Biol Lab, Varanasi 221005, Uttar Pradesh, India
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2019年 / 24卷
关键词：
Cancer metabolism; Lactate; LDH-A; MCTs; monocarboxylate transporters; p53; PFKFB3; Review; CANCER-CELL; AEROBIC GLYCOLYSIS; OXIDATIVE STRESS; GLUCOSE-METABOLISM; ENERGY-METABOLISM; LACTIC-ACID; IN-VITRO; EXPRESSION; DEHYDROGENASE; HYPOXIA;
D O I：
10.2741/4723
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high lactate with acidic pH) in tumor microenvironment. Why tumor microenvironment becomes so responsive towards lactate is still not clear. In this review we have discussed lactate generation and recycling either exogenously, directly or indirectly by cancer cells via some transporters. Tumor cells in hypoxia use glucose rapidly and produce lactate while cells which have profuse oxygen supply take up lactate and use it for energy production which is referred as lactate shuttling between tumor cells. Escaping immune evasion which is also an emerging hallmark of cancer cells has also been discussed in this review with respect of lactate acidosis.
引用
收藏
页码：366 / 381
页数：16
相关论文
共 99 条
[21]   PKM2, cancer metabolism, and the road ahead [J].
Dayton, Talya L. ;
Jacks, Tyler ;
Vander Heiden, Matthew G. .
EMBO REPORTS, 2016, 17 (12) :1721-1730
[22]   Targeting lactate metabolism for cancer therapeutics [J].
Doherty, Joanne R. ;
Cleveland, John L. .
JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (09) :3685-3692
[23]   Microenvironment Changes (in pH) Affect VEGF Alternative Splicing [J].
Elias, Ana Paula ;
Dias, Sergio .
CANCER MICROENVIRONMENT, 2008, 1 (01) :131-139
[24]   Akt stimulates aerobic glycolysis in cancer cells [J].
Elstrom, RL ;
Bauer, DE ;
Buzzai, M ;
Karnauskas, R ;
Harris, MH ;
Plas, DR ;
Zhuang, HM ;
Cinalli, RM ;
Alavi, A ;
Rudin, CM ;
Thompson, CB .
CANCER RESEARCH, 2004, 64 (11) :3892-3899
[25]   HIF, a missing link between metabolism and cancer [J].
Esteban, MA ;
Maxwell, PH .
NATURE MEDICINE, 2005, 11 (10) :1047-1048
[26]   Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance [J].
Fantin, Valeria R. ;
St-Pierre, Julie ;
Leder, Philip .
CANCER CELL, 2006, 9 (06) :425-434
[27]   Lactate Metabolism in Human Lung Tumors [J].
Faubert, Brandon ;
Li, Kevin Y. ;
Cai, Ling ;
Hensley, Christopher T. ;
Kim, Jiyeon ;
Zacharias, Lauren G. ;
Yang, Chendong ;
Do, Quyen N. ;
Doucette, Sarah ;
Burguete, Daniel ;
Li, Hong ;
Huet, Giselle ;
Yuan, Qing ;
Wigal, Trevor ;
Butt, Yasmeen ;
Ni, Min ;
Torrealba, Jose ;
Oliver, Dwight ;
Lenkinski, Robert E. ;
Malloy, Craig R. ;
Wachsmann, Jason W. ;
Young, Jamey D. ;
Kernstine, Kemp ;
DeBerardinis, Ralph J. .
CELL, 2017, 171 (02) :358-+
[28]   Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells [J].
Feron, Olivier .
RADIOTHERAPY AND ONCOLOGY, 2009, 92 (03) :329-333
[29]   Inhibitory effect of tumor cell-derived lactic acid on human T cells [J].
Fischer, Karin ;
Hoffmann, Petra ;
Voelkl, Simon ;
Meidenbauer, Norbert ;
Ammer, Julia ;
Edinger, Matthias ;
Gottfried, Eva ;
Schwarz, Sabine ;
Rothe, Gregor ;
Hoves, Sabine ;
Renner, Kathrin ;
Timischl, Birgit ;
Mackensen, Andreas ;
Kunz-Schughart, Leoni ;
Andreesen, Reinhard ;
Krause, Stefan W. ;
Kreutz, Marina .
BLOOD, 2007, 109 (09) :3812-3819
[30]   Energy deregulation: Licensing tumors to grow [J].
Garber, K .
SCIENCE, 2006, 312 (5777) :1158-1159
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