In vivo visualization of α-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy

被引：79

作者：

Kikuchi, Akio

Takeda, Atsushi ^{[1
]}

Okamura, Nobuyuki ^{[2
]}

Tashiro, Manabu ^{[3
]}

Hasegawa, Takafumi

Furumoto, Shozo ^{[2
,4
]}

Kobayashi, Michiko

Sugeno, Naoto

Baba, Toru

Miki, Yasuo ^{[5
]}

Mori, Fumiaki ^{[5
]}

Wakabayashi, Koichi ^{[5
]}

Funaki, Yoshihito ^{[4
]}

Iwata, Ren ^{[4
]}

Takahashi, Shoki ^{[6
]}

Fukuda, Hiroshi ^{[7
]}

Arai, Hiroyuki ^{[8
]}

Kudo, Yukitsuka ^{[9
]}

Yanai, Kazuhiko ^{[2
]}

Itoyama, Yasuto

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Pharmacol, Sendai, Miyagi 9808574, Japan

[3] Tohoku Univ, Ctr Cyclotron & Radioisotope, Div Cyclotron Nucl Med, Sendai, Miyagi 9808574, Japan

[4] Tohoku Univ, Ctr Cyclotron & Radioisotope, Div Radiopharmaceut Chem, Sendai, Miyagi 9808574, Japan

[5] Hirosaki Univ, Grad Sch Med, Inst Brain Sci, Dept Neuropathol, Hirosaki, Aomori 0368562, Japan

[6] Tohoku Univ, Grad Sch Med, Dept Diagnost Radiol, Sendai, Miyagi 9808574, Japan

[7] Tohoku Univ, Inst Dev Ageing & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi 9808574, Japan

[8] Tohoku Univ, Inst Dev Ageing & Canc, Dept Geriatr & Resp Med, Sendai, Miyagi 9808574, Japan

[9] Tohoku Univ, Innovat New Biomed Engn Ctr, Sendai, Miyagi 9808574, Japan

来源：

BRAIN | 2010年 / 133卷

关键词：

glial cytoplasmic inclusion; Lewy body; beta-amyloid; Parkinson's disease; Pittsburgh compound B; GLIAL CYTOPLASMIC INCLUSIONS; PARKINSONS-DISEASE; CONSENSUS STATEMENT; LEWY BODIES; BINDING; NEUROPATHOLOGY; ACCUMULATION; INVOLVEMENT; DIAGNOSIS; FILAMENTS;

D O I：

10.1093/brain/awq091

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The histopathological hallmark of multiple system atrophy is the appearance of intracellular inclusion bodies, named glial cytoplasmic inclusions, which are mainly composed of alpha-synuclein fibrils. In vivo visualization of alpha-synuclein deposition should be used for the diagnosis and assessment of therapy and severity of pathological progression in multiple system atrophy. Because 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole could stain alpha-synuclein-containing glial cytoplasmic inclusions in post-mortem brains, we compared the carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography findings of eight multiple system atrophy cases to those of age-matched normal controls. The positron emission tomography data demonstrated high distribution volumes in the subcortical white matter (uncorrected P < 0.001), putamen and posterior cingulate cortex (uncorrected P < 0.005), globus pallidus, primary motor cortex and anterior cingulate cortex (uncorrected P < 0.01), and substantia nigra (uncorrected P < 0.05) in multiple system atrophy cases compared to the normal controls. They were coincident with glial cytoplasmic inclusion-rich brain areas in multiple system atrophy and thus, carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography is a promising surrogate marker for monitoring intracellular alpha-synuclein deposition in living brains.

引用

页码：1772 / 1778

页数：7

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