Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma: Case Report, Literature Review, and Proposed Treatment Algorithm

被引：19

作者：

Chapuy, Claudia I. ^{[1
]}

Sahai, Inderneel ^{[2
]}

Sharma, Rohit ^{[2
]}

Zhu, Andrew X. ^{[2
]}

Kozyreva, Olga N. ^{[1
]}

机构：

[1] St Elizabeths Med Ctr, Dana Farber Canc Inst, 736 Cambridge St, Boston, MA 02135 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

来源：

ONCOLOGIST | 2016年 / 21卷 / 04期

关键词：

Fibrolamellar hepatocellular carcinoma; Hyperammonemia; Paraneoplastic hyperammonemia; OTC deficiency; PATIENT;

D O I：

10.1634/theoncologist.2015-0267

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of a 31-year-old man with metastatic fibrolamellar hepatocellular carcinoma (FLHCC) treated with gemcitabine and oxaliplatin complicated by hyperammonemic encephalopathy biochemically consistent with acquired ornithine transcarbamylase deficiency. Awareness of FLHCC-associated hyperammonemic encephalopathy and a pathophysiology-based management approach can optimize patient outcome and prevent serious complications. A discussion of the management, literature review, and proposed treatment algorithm of this rare metabolic complication are presented.

引用

页码：514 / 520

页数：7

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