Bioactive marine alkaloids

被引：117
作者：
Urban, S
Hickford, SJH
Blunt, JW
Munro, MHG [1 ]
机构：
[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand
[2] Natl Inst Water & Atmospher Res Ltd, Auckland, New Zealand
来源：
CURRENT ORGANIC CHEMISTRY | 2000年 / 4卷 / 07期
关键词：
D O I：
10.2174/1385272003376085
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structures, origins, biogenesis, synthesis and bioactivity of a selection of N-heterocyclic marine alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: lamellarins (pyrroles), cephalostatins/ritterazines (pyrazines) and ecteinascidins (isoquinolines). Also discussed are examples of bioactive marine alkaloids that have emerged as novel leads. These include manzamines (beta-carbolines), variolins (pyridopyrrolopyrimidines) and the pyrroloquinoline family. This review emphasises the role of marine alkaloids as an important source of leads for drug discovery.
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收藏
页码：765 / 807
页数：43
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