Synthesis of a new chlorin photosensitizer for photodynamic therapy against colon cancer

被引：5

作者：

Chen, Jianjiao ^{[1
]}

Chen, Zhiqiang ^{[2
]}

Tan, Litao ^{[3
]}

Yang, Jie ^{[3
]}

Shen, Lei ^{[3
]}

Deng, Jun ^{[4
]}

Jiang, Xin ^{[2
]}

Zou, Dengfeng ^{[1
]}

机构：

[1] Guilin Med Univ, Sch Pharm, Guilin 541004, Guangxi, Peoples R China

[2] Guilin Med Univ, Affiliated Hosp, Guilin 541000, Guangxi, Peoples R China

[3] Changshu Inst Technol, Dept Mat Engn, Jiangsu Key Lab Adv Funct Mat, Changshu 215500, Jiangsu, Peoples R China

[4] Jiangsu Univ, Dept Thorac Surg, Kunshan Hosp, Kunshan 215300, Peoples R China

来源：

MATERIALS CHEMISTRY FRONTIERS | 2022年 / 6卷 / 09期

关键词：

OXYGEN QUANTUM YIELD; PHOTOTHERAPY; FLUORESCENCE; PROGRESS;

D O I：

10.1039/d2qm00046f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy (PDT) shows tremendous potential for the treatment of cancer due to its advantages of non-invasiveness and low systemic toxicity. Porphyrin compounds are potentially translatable photosensitizers with excellent biocompatibility for PDT. In this paper, we prepared a new photosensitizer 2-(1-hexyloxyethyl)-2-devinyl porphin e6 trisodium salt (HCE6) to investigate its anti-colon cancer effects and inhibition mechanism on HT-29 and LoVo human colon cancer cells in vitro and in vivo. The results indicate that HCE6, with high phototoxicity and low dark toxicity, is capable of inhibiting the proliferation and metastasis of human colon tumors.

引用

页码：1129 / 1136

页数：8

共 31 条

[1] Chlorin e6-EGF conjugated gold nanoparticles as a nanomedicine based therapeutic agent for triple negative breast cancer [J].

Castilho, Maiara L. ;

Jesus, Viviane P. S. ;

Vieira, Paula F. A. ;

Hewitt, Kevin C. ;

Raniero, L. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2021, 33

[2] A carbazole functionalized semiconducting compound as a heavy atom free photosensitizer for phototherapy against lung cancer [J].

Deng, Jun ;

Zhong, Ning ;

Zhang, Xiaochuan ;

Li, Chang ;

Xu, Chun ;

Zhao, Jun .

JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (47) :10764-10769

[3] Attritional evaluation of lipophilic and hydrophilic metallated phthalocyanines for oncological photodynamic therapy [J].

Dias, Lionel Mendes ;

Sharifi, Farangis ;

de Keijzer, Mark J. ;

Mesquita, Barbara ;

Desclos, Emilie ;

Kochan, Jakub A. ;

de Klerk, Daniel J. ;

Ernst, Daniel ;

de Haan, Lianne R. ;

Franchi, Leonardo P. ;

van Wijk, Albert C. ;

Scutigliani, Enzo M. ;

Cavaco, Jose E. B. ;

Tedesco, Antonio C. ;

Huang, Xuan ;

Pan, Weiwei ;

Ding, Baoyue ;

Krawczyk, Przemek M. ;

Heger, Michal .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2021, 216

[4] Integrating Near-Infrared Visual Fluorescence with a Photoelectrochemical Sensing System for Dual Readout Detection of Biomolecules [J].

Han, Qingzhi ;

Zhao, Xuan ;

Na, Na ;

Ouyang, Jin .

ANALYTICAL CHEMISTRY, 2021, 93 (07) :3486-3492

[5] Recent advances in innovative strategies for enhanced cancer photodynamic therapy [J].

Hu, Tingting ;

Wang, Zhengdi ;

Shen, Weicheng ;

Liang, Ruizheng ;

Yan, Dan ;

Wei, Min .

THERANOSTICS, 2021, 11 (07) :3278-3300

[6] Photodynamic Therapy as a New Treatment for Chronic Rhinosinusitis - A Systematic Review [J].

Kaura, Anika ;

Shukla, Rishi ;

Lamyman, Abigail ;

Almeyda, Robert ;

Draper, Mark ;

Martinez-Devesa, Pablo ;

Qureishi, Ali .

TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY, 2020, 58 (04) :254-267

[7] Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy [J].

Klausen, Maxime ;

Ucuncu, Muhammed ;

Bradley, Mark .

MOLECULES, 2020, 25 (22)

[8] Photodynamic effect of chlorin e6 on cytoskeleton protein of human colon cancer SW480 cells [J].

Ma, Haixiu ;

Yang, Kaizhen ;

Li, Hongxia ;

Luo, Mengyu ;

Wufuer, Reziwan ;

Kang, Ling .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2021, 33

[9] Nanostructured lipid carrier delivering chlorins e6 as in situ dendritic cell vaccine for immunotherapy of gastric cancer [J].

Mao, Mao ;

Liu, Senfeng ;

Zhou, Yiming ;

Wang, Gonghe ;

Deng, Jianping ;

Tian, Lei .

JOURNAL OF MATERIALS RESEARCH, 2020, 35 (23-24) :3257-3264

[10] Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment [J].

Martins, Waleska K. ;

Belotto, Renata ;

Silva, Maryana N. ;

Grasso, Daniel ;

Suriani, Maynne D. ;

Lavor, Tayna S. ;

Itri, Rosangela ;

Baptista, Mauricio S. ;

Tsubone, Tayana M. .

FRONTIERS IN ONCOLOGY, 2021, 10

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