The Role of Antibiotics in Gut Microbiota Modulation: The Eubiotic Effects of Rifaximin

被引：101

作者：

Ponziani, Francesca Romana ^{[1
]}

Scaldaferri, Franco ^{[1
]}

Petito, Valentina ^{[1
,2
]}

Sterbini, Francesco Paroni

Pecere, Silvia ^{[1
]}

Lopetuso, Loris R. ^{[1
]}

Palladini, Alessandra ^{[2
]}

Gerardi, Viviana ^{[1
]}

Masucci, Luca ^{[2
]}

Pompili, Maurizio ^{[1
]}

Cammarota, Giovanni ^{[1
]}

Sanguinetti, Maurizio ^{[2
]}

Gasbarrini, Antonio ^{[1
]}

机构：

[1] A Gemelli Hosp, Internal Med & Gastroenterol Div, Largo A Gemelli 8, IT-00168 Rome, Italy

[2] A Gemelli Hosp, Inst Microbiol, Largo A Gemelli 8, IT-00168 Rome, Italy

来源：

DIGESTIVE DISEASES | 2016年 / 34卷 / 03期

关键词：

Rifaximin; Gut microbiota; Antibiotic; Lactobacillus; Eubiotic; IRRITABLE-BOWEL-SYNDROME; IN-VITRO ACTIVITY; CROHNS-DISEASE; INTESTINAL MICROBIOTA; DOUBLE-BLIND; GASTROINTESTINAL MICROBIOTA; CLOSTRIDIUM-DIFFICILE; DIVERTICULAR-DISEASE; BACTERIA; INFLAMMATION;

D O I：

10.1159/000443361

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Antibiotics are mainly used in clinical practice for their activity against pathogens, but they also alter the composition of commensal gut microbial community. Rifaximin is a non-absorbable antibiotic with additional effects on the gut micro biota about which very little is known. It is still not clear to what extent rifaximin can be able to modulate gut microbiota composition and diversity in different clinical settings. Studies based on culture-dependent techniques revealed that rifaximin treatment promotes the growth of beneficial bacteria, such as Bifidobacteria and Lactobacilli. Accordingly, our metagenomic analysis carried out on patients with different gastrointestinal and liver diseases highlighted a significant increase in Lactobacilli after rifaximin treatment, persisting in the short time period. This result was independent of the disease background and was not accompanied by a significant alteration of the overall gut microbial ecology. This suggests that rifaximin can exert important eubiotic effects independently of the original disease, producing a favorable gut microbiota perturbation without changing its overall composition and diversity. (C) 2016 S. Karger AG, Basel

引用

页码：269 / 278

页数：10

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