The Resurgence of Acyclic Nucleic Acids

被引：27

作者：

Zhang, Su ^{[2
,3
]}

Switzer, Christopher ^{[1
]}

Chaput, John C. ^{[2
,3
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

[2] Arizona State Univ, Ctr Evolutionary Funct Gen, Biodesign Inst, Tempe, AZ 85287 USA

[3] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

来源：

CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 02期

关键词：

TEMPLATE-DIRECTED SYNTHESIS; CRYSTAL-STRUCTURE; NONENZYMATIC OLIGOMERIZATION; NUCLEOSIDE TRIPHOSPHATES; OLIGONUCLEOTIDE ANALOGS; ANGSTROM RESOLUTION; DNA NANOTECHNOLOGY; RIBOSOMAL-SUBUNIT; CHEMICAL ETIOLOGY; DUPLEX FORMATION;

D O I：

10.1002/cbdv.200900281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic-acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self-assembly.

引用

页码：245 / 258

页数：14

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