The Resurgence of Acyclic Nucleic Acids

被引：27
作者：
Zhang, Su [2 ,3 ]
Switzer, Christopher [1 ]
Chaput, John C. [2 ,3 ]
机构：
[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
[2] Arizona State Univ, Ctr Evolutionary Funct Gen, Biodesign Inst, Tempe, AZ 85287 USA
[3] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
来源：
CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 02期
关键词：
TEMPLATE-DIRECTED SYNTHESIS; CRYSTAL-STRUCTURE; NONENZYMATIC OLIGOMERIZATION; NUCLEOSIDE TRIPHOSPHATES; OLIGONUCLEOTIDE ANALOGS; ANGSTROM RESOLUTION; DNA NANOTECHNOLOGY; RIBOSOMAL-SUBUNIT; CHEMICAL ETIOLOGY; DUPLEX FORMATION;
D O I：
10.1002/cbdv.200900281
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic-acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self-assembly.
引用
收藏
页码：245 / 258
页数：14
相关论文
共 64 条
[1]   ISOTACTIC GLYCERO OLIGOTHYMIDYLATE - A CONVENIENT PREPARATION OF (R)-1',2'-SECO-2'-NORTHYMIDINE AND (S)-1',2'-SECO-2'-NORTHYMIDINE [J].
AZYMAH, M ;
CHAVIS, C ;
LUCAS, M ;
MORVAN, F ;
IMBACH, JL .
NUCLEOSIDES & NUCLEOTIDES, 1992, 11 (06) :1241-1255
[2]   The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].
Ban, N ;
Nissen, P ;
Hansen, J ;
Moore, PB ;
Steitz, TA .
SCIENCE, 2000, 289 (5481) :905-920
[3]   ANTIHERPESVIRUS ACTIVITY OF 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE (BRL-39123) IN CELL-CULTURE [J].
BOYD, MR ;
BACON, TH ;
SUTTON, D ;
COLE, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (08) :1238-1242
[4]  
Cairns-Smith A.G., 1982, GENETIC TAKEOVER MIN
[5]   Nonenzymatic oligomerization on templates containing phosphodiester-linked acyclic glycerol nucleic acid analogues [J].
Chaput, JC ;
Switzer, C .
JOURNAL OF MOLECULAR EVOLUTION, 2000, 51 (05) :464-470
[6]   TNA synthesis by DNA polymerases [J].
Chaput, JC ;
Szostak, JW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (31) :9274-9275
[7]   DNA polymerase-mediated DNA synthesis on a TNA template [J].
Chaput, JC ;
Ichida, JK ;
Szostak, JW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (04) :856-857
[8]   ORIGIN OF GENETIC CODE [J].
CRICK, FHC .
JOURNAL OF MOLECULAR BIOLOGY, 1968, 38 (03) :367-&
[9]   Acyclic nucleoside phosphonates: A key class of antiviral drugs [J].
De Clercq, E ;
Holy, A .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (11) :928-940
[10]  
DECLERCQ E, 1987, ANTIVIR RES, V8, P261
1234567