Retrotransposition of Alu elements:: how many sources?

被引：82

作者：

Cordaux, R ^{[1
]}

Hedges, DJ ^{[1
]}

Batzer, MA ^{[1
]}

机构：

[1] Louisiana State Univ, Biol Computat & Visualizat Ctr, Dept Biol Sci, Baton Rouge, LA 70803 USA

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 10期

关键词：

D O I：

10.1016/j.tig.2004.07.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is generally thought that only a few AN elements are capable of retrotransposition and that these 'master' sources produce inactive copies. Here, we use a network phylogenetic approach to demonstrate that recently integrated human-specific Alu subfamilies typically contain 10-20% of secondary source elements that contributed 20-40% of all subfamily members. This multiplicity of source elements provides new insight into the remarkably successful amplification strategy of the Alu family.

引用

页码：464 / 467

页数：4

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