Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season

被引：178

作者：

Linderman, Susanne L. ^{[1
,2
]}

Chambers, Benjamin S. ^{[1
,3
]}

Zost, Seth J. ^{[1
,3
]}

Parkhouse, Kaela ^{[1
]}

Li, Yang ^{[1
,3
]}

Herrmann, Christin ^{[1
,3
]}

Ellebedy, Ali H. ^{[6
,7
]}

Carter, Donald M. ^{[8
]}

Andrews, Sarah F. ^{[9
]}

Zheng, Nai-Ying ^{[9
]}

Huang, Min ^{[9
]}

Huang, Yunping ^{[9
]}

Strauss, Donna ^{[10
]}

Shaz, Beth H. ^{[10
]}

Hodinka, Richard L. ^{[4
,5
]}

Reyes-Teran, Gustavo ^{[11
]}

Ross, Ted M. ^{[8
]}

Wilson, Patrick C. ^{[9
]}

Ahmed, Rafi ^{[6
,7
]}

Bloom, Jesse D. ^{[12
,13
]}

Hensley, Scott E. ^{[1
,2
,3
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Childrens Hosp Philadelphia, Clin Virol Lab, Philadelphia, PA 19104 USA

[6] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[7] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[8] Vaccine & Gene Therapy Inst Florida, Dept Vaccine & Viral Immun, Port St Lucie, FL 34987 USA

[9] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[10] New York Blood Ctr, New York, NY 10065 USA

[11] Natl Inst Resp Dis, Ctr Res Infect Dis, Mexico City 14080, DF, Mexico

[12] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[13] Fred Hutchinson Canc Res Ctr, Computat Biol Program, Seattle, WA 98109 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 44期

基金：

美国国家卫生研究院;

关键词：

influenza; antigenic drift; hemagglutinin; antibody; vaccine; SWINE-ORIGIN; 2009; VIRUS HEMAGGLUTININ; ANTIBODY-RESPONSES; UNITED-STATES; SEPTEMBER; 29; SIN; DETERMINANTS; IMMUNITY; FERRETS; HUMANS;

D O I：

10.1073/pnas.1409171111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Influenza viruses typically cause the most severe disease in children and elderly individuals. However, H1N1 viruses disproportionately affected middle-aged adults during the 2013-2014 influenza season. Although H1N1 viruses recently acquired several mutations in the hemagglutinin (HA) glycoprotein, classic serological tests used by surveillance laboratories indicate that these mutations do not change antigenic properties of the virus. Here, we show that one of these mutations is located in a region of HA targeted by antibodies elicited in many middle-aged adults. We find that over 42% of individuals born between 1965 and 1979 possess antibodies that recognize this region of HA. Our findings offer a possible antigenic explanation of why middle-aged adults were highly susceptible to H1N1 viruses during the 2013-2014 influenza season. Our data further suggest that a drifted H1N1 strain should be included in future influenza vaccines to potentially reduce morbidity and mortality in this age group.

引用

页码：15798 / 15803

页数：6

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