GLUT3 as an Intersection of Glycerophospholipid Metabolism and the Innate Immune Response to Candida albicans

被引：13

作者：

Wu, Xian ^{[1
,2
]}

Zhang, Ge ^{[1
,2
]}

Yang, Wen-Hang ^{[1
,2
,3
]}

Cui, Jing-Tao ^{[1
,2
]}

Zhang, Li ^{[1
,2
]}

Xiao, Meng ^{[1
,2
,3
]}

Xu, Ying-Chun ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Complex Severe & Rare Dis, Peking Union Med Coll Hosp, Dept Lab Med, Beijing, Peoples R China

[2] Peking Union Med Coll Hosp, Beijing Key Lab Mech Res & Precis Diag Invas Fung, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Grad Sch, Peking Union Med Coll, Beijing, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

GLUT3; Candida albicans; innate immune response; glycerophospholipid metabolism; immunometabolic; TRANSPORTER EXPRESSION; GENE-EXPRESSION; HOST-DEFENSE; GLUCOSE; MONOCYTES; CELL; IMMUNOMETABOLISM; INFECTION; DECTIN-1; SENSOR;

D O I：

10.3389/fcimb.2021.648988

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune cells can optimize the management of metabolic resources to balance their energy requirements in order to regulate immune responses. The interconnection between immunometabolism and fungal infections is becoming increasingly apparent. Using proteome and metabolome assays, we found that stimulation of primary human monocytes by Candida albicans was accompanied by upregulation of glucose transporter 3 (GLUT3) and activation of the glycerophospholipid metabolism pathway. Upregulated GLUT3 expression has been preliminarily confirmed in monocytes from patients with C. albicans bloodstream infection. Our findings support the importance of GLUT3 in the complex network of glycerophospholipid metabolism and the innate immune responses against C. albicans. In summary, this study might contribute to decipher the regulatory mechanism between the monocyte metabolic reprogramming and innate immune response and reveal potential targets for the antifungal treatments.

引用

页数：11

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