Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: A case report

被引:36
作者
Fujita, Takayoshi [2 ]
Ando, Takafumi [1 ]
Sakakibara, Masatoshi [2 ]
Hosoda, Waki [3 ]
Goto, Hidemi
机构
[1] Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Aichi Hosp, Aichi Canc Ctr, Dept Gastroenterol, Okazaki, Aichi 4440011, Japan
[3] Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Nagoya, Aichi 4648681, Japan
关键词
Sclerosis; Gastric ulcer; IgG4; Plasma cells; AUTOIMMUNE PANCREATITIS; DISEASE;
D O I
10.3748/wjg.v16.i17.2183
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We describe a 77-year-old man with refractory gastric ulcer that worsened after Helicobacter pylori eradication therapy. Pathology showed marked infiltration of IgG4-positive plasma cells in the gastric lesions, which led us to suspect IgG4-related sclerosing disease. To the best of our knowledge, this is the first report of IgG4-related gastric ulcer without the main manifestation of autoimmune pancreatitis. (C) 2010 Baishideng. All rights reserved.
引用
收藏
页码:2183 / 2186
页数:4
相关论文
共 8 条
[1]  
CHIBA H, 2008, GASTROENTEROL ENDOSC, V50, P1736
[2]   Current concepts - Autoimmune pancreatitis [J].
Finkelberg, Dnitry L. ;
Sahani, Dushyant ;
Deshpande, Vikrarn ;
Brugge, William R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (25) :2670-2676
[3]   A new clinicopathological entity of IgG4-related autoimmune disease [J].
Kamisawa, T ;
Funata, N ;
Hayashi, Y ;
Eishi, Y ;
Koike, M ;
Tsuruta, K ;
Okamoto, A ;
Egawa, N ;
Nakajima, H .
JOURNAL OF GASTROENTEROLOGY, 2003, 38 (10) :982-984
[4]   Pancreatic cancer with a high serum IgG4 concentration [J].
Kamisawa, Terumi ;
Chen, Pong Yui ;
Tu, Yuyang ;
Nakajima, Hitoshi ;
Egawa, Naoto ;
Tsuruta, Kouji ;
Okamoto, Atsutake ;
Hishima, Tsunekazu .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (38) :6225-6228
[5]   Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease [J].
Kamisawa, Terumi ;
Okamoto, Atsutake .
JOURNAL OF GASTROENTEROLOGY, 2006, 41 (07) :613-625
[6]   Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesis [J].
Okazaki, Kazuichi ;
Uchida, Kazushige ;
Fukui, Toshiro .
JOURNAL OF GASTROENTEROLOGY, 2008, 43 (06) :409-418
[7]   Autoimmune pancreatitis is closely associated with gastric ulcer presenting with abundant IgG4-bearing plasma cell infiltration [J].
Shinji, A ;
Sano, K ;
Hamano, H ;
Unno, H ;
Fukushima, M ;
Nakamura, N ;
Akamatsu, T ;
Kawa, S ;
Kiyosawa, K .
GASTROINTESTINAL ENDOSCOPY, 2004, 59 (04) :506-511
[8]   Medical progress:: Helicobacter pylori infection [J].
Suerbaum, S ;
Michetti, P .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (15) :1175-1186