Pleomorphic adenoma: the great mimicker of malignancy

被引：48

作者：

Hernandez-Prera, Juan C. ^{[1
]}

Skalova, Alena ^{[2
]}

Franchi, Alessandro ^{[3
]}

Rinaldo, Alessandra ^{[4
]}

Vander Poorten, Vincent ^{[5
,6
]}

Zbaren, Peter ^{[7
]}

Ferlito, Alfio ^{[8
]}

Wenig, Bruce M. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Pathol, 12902 USF Magnolia Dr, Tampa, FL 33612 USA

[2] Charles Univ Prague, Fac Med Plzen, Dept Pathol, Plzen, Czech Republic

[3] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy

[4] Univ Udine, Dept Otolaryngol, Udine, Italy

[5] Katholieke Univ Leuven, Sect Head & Neck Oncol, Dept Oncol, Leuven, Belgium

[6] Univ Hosp Leuven, Leuven Canc Inst, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[7] Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Bern, Switzerland

[8] Int Head & Neck Sci Grp, Padua, Italy

来源：

HISTOPATHOLOGY | 2021年 / 79卷 / 03期

关键词：

early carcinoma ex pleomorphic adenoma; invasion; MAML2; MYB; oncocytic metaplasia; PLAG1; pleomorphic adenoma; squamous metaplasia;

D O I：

10.1111/his.14322

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm, and its diagnosis is straightforward in the majority of cases. However, not infrequently, PA shows unusual and uncommon histological features that can be confused with those of malignancy. The difficulties in diagnosing PA arise from its ability to mimic invasion, show atypical or metaplastic cytomorphology, and show morphological features that overlap with those of established salivary gland carcinomas. In addition, recognising early malignant transformation to carcinoma ex-pleomorphic adenoma continues to be a frequent challenge. This review describes the diagnostic pitfalls of PA, and offers a systematic approach to avoid them by combining classic histopathology with novel immunohistochemical and molecular tests.

引用

页码：279 / 290

页数：12

共 63 条

[1] NECROSIS IN BENIGN SALIVARY-GLAND NEOPLASMS - NOT NECESSARILY A SIGN OF MALIGNANT TRANSFORMATION [J].

ALLEN, CM ;

DAMM, D ;

NEVILLE, B ;

RODU, B ;

PAGE, D ;

WEATHERS, DR .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1994, 78 (04) :455-461

[2] Intra-vascular tumour in pleomorphic adenomas - A report of four cases [J].

Altini, M ;

Coleman, H ;

Kienle, F .

HISTOPATHOLOGY, 1997, 31 (01) :55-59

[3]

Auclair PL, 1996, MODERN PATHOL, V9, P652

[4] PLAG1: An Immunohistochemical Marker with Limited Utility in Separating Pleomorphic Adenoma from Other Basaloid Salivary Gland Tumors [J].

Avadhani, Vaidehi ;

Cohen, Cynthia ;

Siddiqui, Momin T. .

ACTA CYTOLOGICA, 2016, 60 (03) :240-245

[5] What is hiding behind S100 protein and SOX10 positive oncocytomas? Oncocytic pleomorphic adenoma and myoepithelioma with novel gene fusions in a subset of cases [J].

Baneckova, Martina ;

Uro-Coste, Emmanuelle ;

Ptakova, Nikola ;

Steiner, Petr ;

Stanowska, Olga ;

Benincasa, Giulio ;

Colella, Giuseppe ;

Vondrak, Jan ;

Michal, Michal ;

Leivo, Ilmo ;

Skalova, Alena .

HUMAN PATHOLOGY, 2020, 103 :52-62

[6] Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms [J].

Brill, Louis B., II ;

Kanner, William A. ;

Fehr, Andre ;

Andren, Ywonne ;

Moskaluk, Christopher A. ;

Loening, Thomas ;

Stenman, Goran ;

Frierson, Henry F., Jr. .

MODERN PATHOLOGY, 2011, 24 (09) :1169-1176

[7] Mechanisms of coagulative necrosis in malignant epithelial tumors [J].

Carus, Rosario A. ;

Branca, Giovanni ;

Fedele, Francesco ;

Irato, Eleonora ;

Finocchiaro, Giuseppe ;

Parisi, Antonio ;

Ieni, Antonio .

ONCOLOGY LETTERS, 2014, 8 (04) :1397-1402

[8]

Coleman H, 1999, HISTOPATHOLOGY, V35, P439

[9] Loss of expression of Plag1 in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma [J].

de Brito, Beatriz Samara ;

Giovanelli, Natalia ;

Egg, Erika Said ;

Sanchez-Romero, Celeste ;

do Nascimento, Juliana de Souza ;

Martins, Antonio Santos ;

Tincani, Alfio Jose ;

Del Negro, Andre ;

Gondak, Rogerio de Oliveira ;

de Almeida, Oslei Paes ;

Kowalski, Luiz Paulo ;

Altemani, Albina ;

Mariano, Fernanda Viviane .

HUMAN PATHOLOGY, 2016, 57 :152-159

[10] Non-invasive (intracapsular) carcinoma ex pleomorphic adenoma:: recognition of focal carcinoma by HER-2/neu and MIB1 immunohistochemistry [J].

Di Palma, S ;

Skálová, A ;

Vanìèek, T ;

Simpson, RHW ;

Stárek, I ;

Leivo, I .

HISTOPATHOLOGY, 2005, 46 (02) :144-152

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