Drug transporters in the nasal epithelium: an overview of strategies in targeted drug delivery

被引:24
作者
Anand, Utkarshini [1 ]
Parikh, Ankit [1 ]
Ugwu, Malachy C. [1 ]
Agu, Remigius U. [1 ]
机构
[1] Coll Pharm, Biopharmaceut & Drug Delivery Lab, Halifax, NS B3H 4R2, Canada
关键词
ORGANIC ANION TRANSPORTER; COUPLED OLIGOPEPTIDE TRANSPORTER; AMINO-ACID TRANSPORTERS; CYSTIC-FIBROSIS; P-GLYCOPROTEIN; OLFACTORY MUCOSA; CATION TRANSPORTERS; MOLECULAR-CLONING; DOPAMINE TRANSPORTER; RAT-BRAIN;
D O I
10.4155/fmc.14.77
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
In this article, we discussed the expression of some ABC (e.g., P-glycoprortein, MRP and CFTR) and SLC (e.g., POT, DAT, OAT, OATP, OCT, EAAT2/GLT1 and GLUT) amino acid, metal and nucleoside transporters in the nasal mucosa. The localization and therapeutic targeting of these transporters are explored in detail. The wide array of transporters discovered so far in the nasal mucosa implies that a plethora of compounds can be delivered by targeting these transporters. The article concludes with a discussion of the potential challenges and delivery options for transporter-mediated drug targeting via the nasal route.
引用
收藏
页码:1381 / 1397
页数:17
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