PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update

被引：198
作者：
Makker, Annu [1 ]
Goel, Madhu Mati [1 ]
Mahdi, Abbas Ali [2 ]
机构：
[1] King Georges Med Univ, Postgrad Dept Pathol, Lucknow 226003, Uttar Pradesh, India
[2] King Georges Med Univ, Dept Biochem, Lucknow 226003, Uttar Pradesh, India
来源：
JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2014年 / 53卷 / 03期
关键词：
PI3K/PTEN/Akt and TSC/mTOR pathways; ovarian function; oogenesis; folliculogenesis; infertility; FOLLICLE-STIMULATING-HORMONE; PROTEIN-KINASE-B; OOCYTE-SPECIFIC DELETION; PRIMORDIAL GERM-CELLS; GRANULOSA-CELLS; GROWTH-FACTOR; IN-VITRO; MEIOTIC MATURATION; MOUSE OOCYTES; KIT-LIGAND;
D O I：
10.1530/JME-14-0220
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Abnormalities in ovarian function, including defective oogenesis and folliculogenesis, represent a key female reproductive deficiency. Accumulating evidence in the literature has shown that the PI3K/PTEN/Akt and TSC/mTOR signaling pathways are critical regulators of ovarian function including quiescence, activation, and survival of primordial follicles, granulosa cell proliferation and differentiation, and meiotic maturation of oocytes. Dysregulation of these signaling pathways may contribute to infertility caused by impaired follicular development, intrafollicular oocyte development, and ovulation. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/Akt and TSC/mTOR pathways during mammalian oogenesis and folliculogenesis and their association with female infertility.
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收藏
页码：R103 / R118
页数：16
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