Programmed necrosis and necroptosis signalling

被引:147
作者
Feoktistova, Maria [1 ]
Leverkus, Martin [1 ]
机构
[1] Heidelberg Univ, Med Fac Mannheim, Dept Dermatol Venereol & Allergol, Mol Dermatol Sect, D-68167 Mannheim, Germany
关键词
cellular FLICE-inhibitory protein (cFLIP) isoforms; necroptosis; receptor-interacting serine; threonine protein kinase 1; threonine protein kinase 3; ripoptosome; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; MYELOID-LEUKEMIA CELLS; KAPPA-B ACTIVATION; L929; CELLS; MOLECULAR-MECHANISMS; REGULATED NECROSIS; IN-VIVO; DEATH; TNF;
D O I
10.1111/febs.13120
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor-interacting serine/threonine protein kinase1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like protein, and the molecular signalling platforms in which these molecules participate, are being intensively studied. In particular, the role of RIPK1, being both a kinase and a scaffold molecule, in different cell death regulatory complexes is of great relevance for the field. This minireview aims to introduce the emerging and dynamic field of necroptosis to the reader, with a specific focus on intracellular signalling pathways involved in this process.
引用
收藏
页码:19 / 31
页数:13
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