A case series of lacosamide as adjunctive therapy in refractory sleep-related hypermotor epilepsy (previously nocturnal frontal lobe epilepsy)

被引：10
作者：
Samarasekera, Shanika R. [1 ]
Berkovic, Samuel F. [1 ]
Scheffer, Ingrid E. [1 ,2 ]
机构：
[1] Univ Melbourne, Epilepsy Res Ctr, Dept Med, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
来源：
JOURNAL OF SLEEP RESEARCH | 2018年 / 27卷 / 05期
关键词：
antiepileptic drugs; frontal lobe epilepsy; ORAL LACOSAMIDE; SUBUNIT;
D O I：
10.1111/jsr.12669
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of this study was to evaluate the efficacy and tolerability of open-label lacosamide in patients with refractory sleep-related hypermotor epilepsy. The study was a case review of eight patients with refractory sleep-related hypermotor epilepsy treated with lacosamide. Seizure diaries compared the mean baseline seizure frequency with the most recent 3months of follow-up. Five (62.5%) patients were responders, defined as 50% reduction in seizure frequency, over a mean duration of exposure of 21.5months. The mean maintenance dose of lacosamide was 400mg/day. No-one reported worsening of seizures. Lacosamide was well tolerated with initial fatigue being the main side-effect. Lacosamide is a potentially efficacious adjunctive therapy in patients with refractory sleep-related hypermotor epilepsy. A double-blind placebo-controlled study would determine its efficacy.
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