Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections

被引：4

作者：

Kot, Karolina ^{[1
]}

Lanocha-Arendarczyk, Natalia ^{[1
]}

Ptak, Michal ^{[2
]}

Lanocha, Aleksandra ^{[3
]}

Kalisinska, Elzbieta ^{[1
]}

Kosik-Bogacka, Danuta ^{[4
]}

机构：

[1] Pomeranian Med Univ, Dept Biol & Med Parasitol, Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland

[2] Pomeranian Med Univ, Dept Nephrol Transplantol & Internal Med, PowstancowWielkopolskich 72, PL-70111 Szczecin, Poland

[3] Pomeranian Med Univ, Dept Haematol & Transplantol, Unii Lubelskiej 1, PL-71252 Szczecin, Poland

[4] Pomeranian Med Univ, Independent Lab Pharmaceut Bot, Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 08期

关键词：

Acanthamoeba spp; kidneys; Leishmania spp; Plasmodium spp; Toxoplasma gondii; TOLL-LIKE RECEPTORS; PLASMODIUM-FALCIPARUM MALARIA; FREE-LIVING AMEBAS; INJURY MOLECULE-1; TOXOPLASMA-GONDII; MATRIX METALLOPROTEINASES; ACANTHAMOEBA SPP; OXIDATIVE STRESS; LIPOCALIN NGAL; RENAL INJURY;

D O I：

10.3390/ijms22084209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leishmaniasis, malaria, toxoplasmosis, and acanthamoebiasis are protozoan parasitic infections. They remain important contributors to the development of kidney disease, which is associated with increased patients' morbidity and mortality. Kidney injury mechanisms are not fully understood in protozoan parasitic diseases, bringing major difficulties to specific therapeutic interventions. The aim of this review is to present the biochemical and molecular mechanisms in kidneys infected with Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Acanthamoeba spp. We present available mechanisms of an immune response, oxidative stress, apoptosis process, hypoxia, biomarkers of renal injury in the serum or urine, and the histopathological changes of kidneys infected with the selected parasites. Pathomechanisms of Leishmania spp. and Plasmodium spp. infections have been deeply investigated, while Toxoplasma gondii and Acanthamoeba spp. infections in the kidneys are not well known yet. Deeper knowledge of kidney involvement in leishmaniasis and malaria by presenting their mechanisms provides insight into how to create novel and effective treatments. Additionally, the presented work shows gaps in the pathophysiology of renal toxoplasmosis and acanthamoebiasis, which need further research.

引用

页数：24