Malignant melanoma in albino water buffalo (Bubalus bubalis)

被引：3

作者：

Florisbal Dame, Maria Cecelia ^{[1
]}

Marcolongo-Pereira, Clairton ^{[2
]}

Fiss, Leticia ^{[3
]}

Adrien, Maria de Lourdes ^{[4
]}

Schild, Ana Lucia ^{[5
]}

机构：

[1] EMBRAPA Clima Temperado, Med Vet, Capao Do Leao, RS, Brazil

[2] UniRitter, Ctr Educ Ritter Reis, Fac Vet, Porto Alegre, RS, Brazil

[3] Univ Fed Pelotas, Programa Posgrad Vet, Pelotas, RS, Brazil

[4] Univ Republ, Med Vet, UDELAR, Paysandu, Uruguay

[5] Univ Fed Pelotas, Lab Reg Diagnost, Med Vet, Pelotas, RS, Brazil

来源：

SEMINA-CIENCIAS AGRARIAS | 2015年 / 36卷 / 05期

关键词：

Albinism; water buffalo; immunohistochemistry; malignant melanoma; CUTANEOUS MELANOMA;

D O I：

10.5433/1679-0359.2015v36n5p3239

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Two albino water buffalo affected by multiple melanocytic tumors in Southern Brazil are described. Grossly, there were multiple dark tumors within the skin, skeletal muscle, lungs, and lymph nodes. The tumor was also present in the pericardial sac, renal capsule, mediastinum and pleura. Microscopically, the tumors consisted of polyhedral epithelioid cells arranged in solid nests or interwoven fascicles supported by a thin and sparse collagenous stroma. The cytoplasm was eosinophilic and sometimes contained varying amounts of melanin pigment. The mitotic rates were low. Immunohistochemistry staining with Tyrosinase, Melan-A, Vimentin, S-100 protein, and neurofilament were positive. It is possible that the polymorphisms related to pigmentation in albino buffalo contributed with a high risk of developing melanoma as suggested in humans.

引用

页码：3239 / 3244

页数：6

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