Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

被引：37

作者：

Hart, Phil A. ^{[1
]}

Andersen, Dana K. ^{[2
]}

Mather, Kieren J. ^{[3
]}

Castonguay, Alicia C. ^{[4
,5
]}

Bajaj, Mandeep ^{[6
]}

Bellin, Melena D. ^{[7
]}

Bradley, David ^{[8
]}

Contreras, Noemy ^{[4
]}

Habtezion, Aida ^{[9
]}

Korc, Murray ^{[10
,11
,12
,13
,14
]}

Kudva, Yogish ^{[15
]}

Petrov, Maxim S. ^{[16
]}

Whitcomb, David C. ^{[17
,18
,19
]}

Yadav, Dhiraj ^{[20
]}

Yuan, Ying ^{[4
]}

Rinaudo, Jo Ann S. ^{[21
]}

Srivastava, Sudhir ^{[21
]}

Serrano, Jose ^{[2
]}

Goodarzi, Mark O. ^{[22
]}

机构：

[1] Ohio State Univ, Div Gastroenterol Hepatol & Nutr, Wexner Med Ctr, 410 West Tenth Ave, Columbus, OH 43210 USA

[2] NIDDK, Div Digest Dis & Nutr, NIH, Bethesda, MD 20892 USA

[3] Indiana Univ Sch Med, Div Endocrinol & Metab, Indianapolis, IN 46202 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[5] Univ Toledo, Coll Med, Dept Neurol, 2801 W Bancroft St, Toledo, OH 43606 USA

[6] Baylor Coll Med, Sect Endocrinol Diabet & Metab, Houston, TX 77030 USA

[7] Univ Minnesota, Sch Med, Dept Pediat & Surg, Minneapolis, MN 55455 USA

[8] Ohio State Univ, Div Endocrinol Diabet & Metab, Diabet & Metab Res Ctr, Wexner Med Ctr, Columbus, OH 43210 USA

[9] Stanford Univ, Dept Med, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

[10] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[11] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[12] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[13] Melvin & Bren Simon Canc Ctr, Indianapolis, IN USA

[14] Pancreat Canc Signature Ctr, Indianapolis, IN USA

[15] Mayo Clin, Div Endocrinol, Coll Med, Rochester, MN USA

[16] Univ Auckland, Dept Surg, Auckland, New Zealand

[17] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[18] Univ Pittsburgh, Dept Cell Biol & Mol Physiol, Pittsburgh, PA USA

[19] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA

[20] Univ Pittsburgh, Med Ctr, Div Gastroenterol & Hepatol, Pittsburgh, PA USA

[21] NCI, Canc Biomarker Res Grp, Canc Prevent Div, NIH, Rockville, MD USA

[22] Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA

来源：

PANCREAS | 2018年 / 47卷 / 10期

关键词：

type 3c diabetes mellitus; pancreatic polypeptide; insulin; glucagon; incretin hormone; ABNORMAL GLUCOSE-METABOLISM; MELLITUS SECONDARY; POLYPEPTIDE RESPONSE; INSULIN-RESISTANCE; EXOCRINE PANCREAS; PLASMA-LEVELS; PREVALENCE; REVERSAL; DISEASES; GIP;

D O I：

10.1097/MPA.0000000000001168

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study, that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.

引用

页码：1239 / 1243

页数：5

共 50 条

[1]

Andersen DK, 2013, PANCREAS, V42, P1227, DOI 10.1097/MPA.0b013e3182a9ad9d

[2] Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States [J].

Bellin, Melena D. ;

Whitcomb, David C. ;

Abberbock, Judah ;

Sherman, Stuart ;

Sandhu, Bimaljit S. ;

Gardner, Timothy B. ;

Anderson, Michelle A. ;

Lewis, Michele D. ;

Alkaade, Samer ;

Singh, Vikesh K. ;

Baillie, John ;

Banks, Peter A. ;

Conwell, Darwin ;

Cote, Gregory A. ;

Guda, Nalini M. ;

Muniraj, Thiruvengadam ;

Tang, Gong ;

Brand, Randall E. ;

Gelrud, Andres ;

Amann, Stephen T. ;

Forsmark, Christopher E. ;

Wilcox, C. Mel ;

Slivka, Adam ;

Yadav, Dhiraj .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2017, 112 (09) :1457-1465

[3]

Briani G, 1988, J Diabet Complications, V2, P50, DOI 10.1016/0891-6632(88)90030-X

[4] Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk [J].

Brodovicz, K. G. ;

Kou, T. D. ;

Alexander, C. M. ;

O'Neill, E. A. ;

Engel, S. S. ;

Girman, C. J. ;

Goldstein, B. J. .

DIABETES OBESITY & METABOLISM, 2012, 14 (12) :1123-1128

[5] Pancreatic polypeptide administration improves abnormal glucose metabolism in patients with chronic pancreatitis [J].

Brunicardi, FC ;

Chaiken, RL ;

Ryan, AS ;

Seymour, NE ;

Hoffmann, JA ;

Lebovitz, HE ;

Chance, RE ;

Gingerich, RL ;

Andersen, DK ;

Elahi, D .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (10) :3566-3572

[6]

CERSOSIMO E, 1991, CANCER, V67, P486, DOI 10.1002/1097-0142(19910115)67:2<486::AID-CNCR2820670228>3.0.CO

[7]

2-1

[8] Pancreatic cancer-associated diabetes mellitus: Prevalence and temporal association with diagnosis of cancer [J].

Chari, Suresh T. ;

Leibson, Cynthia L. ;

Rabe, Kari G. ;

Timmons, Lawrence J. ;

Ransom, Jeanine ;

De Andrade, Mariza ;

Petersen, Gloria M. .

GASTROENTEROLOGY, 2008, 134 (01) :95-101

[9] THE PREVALENCE OF RETINOPATHY IS SIMILAR IN DIABETES-MELLITUS SECONDARY TO CHRONIC-PANCREATITIS WITH OR WITHOUT PANCREATECTOMY AND IN IDIOPATHIC DIABETES-MELLITUS [J].

COUET, C ;

GENTON, P ;

POINTEL, JP ;

LOUIS, J ;

GROSS, P ;

SAUDAX, E ;

DEBRY, G ;

DROUIN, P .

DIABETES CARE, 1985, 8 (04) :323-328

[10] Diabetes and pancreatic cancer [J].

Cui, YunFeng ;

Andersen, Dana K. .

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