Ruthenium(II)-Catalyzed C-H Alkynylation of Weakly Coordinating Benzoic Acids

被引：55

作者：

Mei, Ruhuai ^{[1
]}

Zhang, Shou-Kun ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Georg August Univ, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 12期

基金：

欧洲研究理事会;

关键词：

CATALYZED DIRECT ALKYNYLATION; CARBOXYLIC-ACIDS; C(SP(3))-H BONDS; ARYLATION; ARENES; ARYL; FUNCTIONALIZATION; ACTIVATION; HYDROARYLATION; ALKYNES;

D O I：

10.1021/acs.orglett.7b01294

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-H alkynylations with weakly coordinating aide accomplished by the aid of an expedient ruthenium(II) catalysis manifold. The user-friendly C-H alkynylation occurred under mild conditions with the weak base K2CO3. The versatility of the ruthenium(II) catalysis was reflected by providing;step-economical access to phthalides as well as enabling unprecedented decarboxylative ortho-C-H alkynylations.

引用

页码：3171 / 3174

页数：4

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