The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - Lessons learned from experimental models

被引：58

作者：

Aguilera, Monica ^{[1
,2
]}

Darby, Trevor ^{[3
]}

Melgar, Silvia ^{[3
]}

机构：

[1] Univ Autonoma Barcelona, Dept Cell Biol Physiol & Immunol, E-08193 Barcelona, Spain

[2] Univ Autonoma Barcelona, Inst Neurosci, E-08193 Barcelona, Spain

[3] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 06期

基金：

爱尔兰科学基金会;

关键词：

Inflammasomes; Microbiota; IBD; Colitis-associated cancer; Caspase-1; DEXTRAN SULFATE SODIUM; NOD-LIKE RECEPTOR; CHRONIC INTESTINAL INFLAMMATION; ACTIVE ULCERATIVE-COLITIS; INNATE IMMUNE RECOGNITION; KAPPA-B ACTIVATION; CROHNS-DISEASE; NLRP3; INFLAMMASOME; AIM2; HOST-DEFENSE;

D O I：

10.1016/j.cytogfr.2014.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammasomes are a large family of multiprotein complexes recognizing pathogen-associated molecular pattern molecules (PAMPs) and damage-associated molecular patterns (DAMPS). This leads to caspase-1 activation, promoting the secretion of mature IL-1 beta, IL-18 and under certain conditions even induce pyroptosis. Inflammatory Bowel Diseases (IBD) is associated with alterations in microbiota composition, inappropriate immune responses and genetic predisposition associated to bacterial sensing and autophagy. Besides their acknowledged role in mounting microbial induced host responses, a crucial role in maintenance of intestinal homeostasis was revealed in inflammasome deficient mice. Further, abnormal activation of these functions appears to contribute to the pathology of intestinal inflammation including IBD and colitis-associated cancer. Herein, the current literature implicating the inflammasomes, microbiota and IBD is comprehensively reviewed. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：715 / 730

页数：16

共 164 条

[31] The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases [J].

Davis, Beckley K. ;

Wen, Haitao ;

Ting, Jenny P. -Y. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :707-735

[32]

De la Fuente M, 2014, INT J MED MICROBIOL

[33] Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma [J].

DeYoung, KL ;

Ray, ME ;

Su, YA ;

Anzick, SL ;

Johnstone, RW ;

Trapani, JA ;

Meltzer, PS ;

Trent, JM .

ONCOGENE, 1997, 15 (04) :453-457

[34] Immunological and Inflammatory Functions of the Interleukin-1 Family [J].

Dinarello, Charles A. .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :519-550

[35] Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis [J].

Dubuquoy, L ;

Jansson, EÅ ;

Deeb, S ;

Rakotobe, S ;

Karoui, M ;

Colombel, JF ;

Auwerx, J ;

Pettersson, S ;

Desreumaux, P .

GASTROENTEROLOGY, 2003, 124 (05) :1265-1276

[36] Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases [J].

Dupaul-Chicoine, Jeremy ;

Yeretssian, Garabet ;

Doiron, Karine ;

Bergstrom, Kirk S. B. ;

McIntire, Christian R. ;

LeBlanc, Philippe M. ;

Meunier, Charles ;

Turbide, Claire ;

Gros, Philippe ;

Beauchemin, Nicole ;

Vallance, Bruce A. ;

Saleh, Maya .

IMMUNITY, 2010, 32 (03) :367-378

[37] Integrative inflammasome activity in the regulation of intestinal mucosal immune responses [J].

Elinav, E. ;

Henao-Mejia, J. ;

Flavell, R. A. .

MUCOSAL IMMUNOLOGY, 2013, 6 (01) :4-13

[38] Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms [J].

Elinav, Eran ;

Nowarski, Roni ;

Thaiss, Christoph A. ;

Hu, Bo ;

Jin, Chengcheng ;

Flavell, Richard A. .

NATURE REVIEWS CANCER, 2013, 13 (11) :759-771

[39]

Elinav Eran, 2013, Methods Mol Biol, V1040, P185, DOI 10.1007/978-1-62703-523-1_14

[40] NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis [J].

Elinav, Eran ;

Strowig, Till ;

Kau, Andrew L. ;

Henao-Mejia, Jorge ;

Thaiss, Christoph A. ;

Booth, Carmen J. ;

Peaper, David R. ;

Bertin, John ;

Eisenbarth, Stephanie C. ;

Gordon, Jeffrey I. ;

Flavell, Richard A. .

CELL, 2011, 145 (05) :745-757

← 1 2 3 4 5 6 7 8 9 10 →