Regulation of the germinal center response by microRNA-155

被引：1215

作者：

Thai, To-Ha

Calado, Dinis Pedro

Casola, Stefano

Ansel, K. Mark

Xiao, Changchun

Xue, Yingzi

Murphy, Andrew

Frendewey, David

Valenzuela, David

Kutok, Jeffery L.

Schmidt-Supprian, Marc

Rajewsky, Nikolaus

Yancopoulos, George

Rao, Anjana

Rajewsky, Klaus ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA

[2] IFOM FIRC Inst Mol Oncol, I-20139 Milan, Italy

[3] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

[4] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[5] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

来源：

SCIENCE | 2007年 / 316卷 / 5824期

关键词：

D O I：

10.1126/science.1141229

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

引用

收藏

页码：604 / 608

页数：5

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