Chemoenzymatic arabinosylation of 2-aminopurines bearing the chiral fragment of 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines

被引：9

作者：

Eletskaya, Barbara Z. ^{[1
]}

Konstantinova, Irina D. ^{[1
]}

Paramonov, Alexander S. ^{[1
]}

Esipov, Roman S. ^{[1
]}

Gruzdev, Dmitry A. ^{[2
]}

Vigorov, Alexey Yu. ^{[2
]}

Levit, Galina L. ^{[2
]}

Miroshnikov, Anatoly I. ^{[1
]}

Krasnov, Victor P. ^{[2
]}

Charushin, Valery N. ^{[2
]}

机构：

[1] Russian Acad Sci, MM Shemyakin Yu A Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[2] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, Ekaterinburg 620990, Russia

来源：

MENDELEEV COMMUNICATIONS | 2016年 / 26卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

ADENOSINE RECEPTOR AGONISTS; TRIFLUOROACETIC-ACID; PURINE DERIVATIVES; CELL-DEATH; INHIBITORS; NUCLEOSIDES; CLOFARABINE; LIGANDS; ANALOGS; KINASE;

D O I：

10.1016/j.mencom.2016.01.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemoenzymatic transglycosylation of 2-aminopurine conjugates with enantiomerically pure 7,8-difiuoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines under the action of recombinant E. coli purine nucleoside phosphorylase afforded the corresponding arabinofuranosides, yields of the target compounds being dependent on both the structure and configuration of the fragment of heterocyclic amine attached at C-6 position of purine moiety.

引用

页码：6 / 8

页数：3

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