Impact of Isolated High Home Systolic Blood Pressure and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A 5-Year Prospective Cohort Study

被引：1

作者：

Kitagawa, Nobuko ^{[1
]}

Kitagawa, Noriyuki ^{[1
,2
]}

Ushigome, Emi ^{[1
]}

Ushigome, Hidetaka ^{[3
]}

Yokota, Isao ^{[4
]}

Nakanishi, Naoko ^{[1
]}

Hamaguchi, Masahide ^{[1
]}

Asano, Mai ^{[1
]}

Yamazaki, Masahiro ^{[1
]}

Fukui, Michiaki ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto 6028566, Japan

[2] Kameoka Municipal Hosp, Dept Endocrinol & Metab, Kyoto 6218585, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Organ Transplantat & Gen Surg, Kyoto 6028566, Japan

[4] Hokkaido Univ, Grad Sch Med, Dept Biostat, Sapporo, Hokkaido 0608638, Japan

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 09期

关键词：

albuminuria; diabetes mellitus; isolated high home systolic blood pressure; diabetic nephropathy; CARDIOVASCULAR RISK-FACTORS; HEART-FAILURE; HYPERTENSION; DISEASE; MANAGEMENT; SOCIETY; PROGNOSIS; EXCRETION; STIFFNESS; ADULTS;

D O I：

10.3390/jcm10091929

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: A previous 2-year cohort study has shown that isolated high home systolic blood pressure (IH-HSBP) may increase the risk of diabetic nephropathy, using normal HBP as a reference. However, this association has not been previously assessed in the medium to long term. Methods: This prospective 5-year cohort study of 424 patients, with normal or mildly increased albuminuria, investigated the effect of IH-HSBP on the risk of diabetic nephropathy in patients with type 2 diabetes mellitus. Diabetic nephropathy was defined as an advancement from normal or mildly increased albuminuira to moderate or severely increased albuminuria. Results: Among 424 patients, 75 developed diabetic nephropathy during the study period. The adjusted odds ratio for developing diabetic nephropathy given IH-HSBP was 2.39 (95% confidence interval, 1.15-4.96, p = 0.02). The odds ratio for developing nephropathy in patients with IH-HSBP younger than 65 years was higher than that in patients with IH-HSBP older than 65 years. Conclusion: IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports. These findings suggest that IH-HSBP might be a useful marker in disease prognostication.

引用

页数：11

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