Overexpression of MCM6 predicts poor survival in patients with glioma

被引：36
作者：
Cai, Hong-Qing [1 ,2 ]
Cheng, Zhi-Jian [1 ,2 ]
Zhang, Hai-Peng [1 ,2 ]
Wang, Peng-Fei [4 ]
Zhang, Yu [2 ,3 ]
Hao, Jia-Jie [2 ,3 ]
Wang, Ming-Rong [2 ,3 ]
Wan, Jing-Hai [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept Neurosurg, Beijing 100021, Peoples R China
[2] Peking Union Med Coll, Beijing 100021, Peoples R China
[3] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
[4] Capital Med Univ, Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China
来源：
HUMAN PATHOLOGY | 2018年 / 78卷
基金：
中国国家自然科学基金;
关键词：
Minichromosome maintenance proteins; Glioma; Biomarker; Molecular subtype; MCM6; MINICHROMOSOME MAINTENANCE PROTEIN-7; PROGNOSTIC TUMOR-MARKERS; DNA-DAMAGE SITES; HOMOLOGOUS RECOMBINATION; UNITED-STATES; RECRUITMENT; REPLICATION; COMPLEX; BRAIN;
D O I：
10.1016/j.humpath.2018.04.024
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Minichromosome maintenance proteins (MCMs) play an essential role in DNA replication and other cellular activities. However, their expression levels and clinical value in glioma are unclear. In the present study, we analyzed the relationship between MCM mRNA expression and clinical parameters in 325 gliomas and found that MCM6 presented high expression and was associated with poor survival. Immunohistochemistry analysis of an independent data set of 423 glioma tissues confirmed the overexpression of MCM6 protein, especially in glioblastomas with shorter overall survival. Importantly, a combination of MCM6 overexpression with IDH1 mutation further improved the prediction of the prognosis of glioblastomas. Patients with IDH1 mutation and low MCM6 expression exhibited the longest survival, whereas those with high MCM6 expression and wild-type IDH1 showed the shortest. Collectively, our observation indicates that MCM6 is a novel potential biomarker for predicting poor prognosis of the patients with glioma. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：182 / 187
页数：6
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