Thermal compact modeling approach of droplet microreactor based Lab-on-a-Chip devices

被引：4

作者：

Ender, Ferenc ^{[1
]}

Nemeth, Marton ^{[1
]}

Palovics, Peter ^{[1
]}

Drozdy, Andras ^{[1
]}

Poppe, Andras ^{[1
]}

机构：

[1] Univ Budapest Technol & Econ, Dept Electron Devices, H-117 Budapest, Hungary

来源：

MICROELECTRONICS JOURNAL | 2014年 / 45卷 / 12期

关键词：

Compact thermal modeling; Segmented slug flow; Lab-on-a-Chip; Calorimetry; Thermal aware design; FLOW; CALORIMETERS; MEMS;

D O I：

10.1016/j.mejo.2014.07.005

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The paper presents a novel compact model which enables the thermal analysis of microchannels consisting of continuously moving microdroplets with biologically active content inside. The compact model utilizes the switched capacitor approach to describe the convective heat transfer and as a behavioral model, it can be easily integrated into an IC-MEMS design How. With this novel approach the temperature profile of the channel can be calculated in minutes compared to conventional numerical techniques that requires days or weeks. The model was validated by a standard CFD solver and a good match was achieved. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1786 / 1794

页数：9

共 18 条

[1] Review of automated design and optimization of MEMS [J].

Achiche, Sofiane ;

Fan, Zhun ;

Bolognini, Francesca .

2007 IEEE INTERNATIONAL SYMPOSIUM ON INDUSTRIAL ELECTRONICS, PROCEEDINGS, VOLS 1-8, 2007, :2150-+

[2] Validation of a CFD model of Taylor flow hydrodynamics and heat transfer [J].

Asadolahi, Azadeh N. ;

Gupta, Raghvendra ;

Leung, Sharon S. Y. ;

Fletcher, David F. ;

Haynes, Brian S. .

CHEMICAL ENGINEERING SCIENCE, 2012, 69 (01) :541-552

[3] CFD approaches for the simulation of hydrodynamics and heat transfer in Taylor flow [J].

Asadolahi, Azadeh N. ;

Gupta, Raghvendra ;

Fletcher, David F. ;

Haynes, Brian S. .

CHEMICAL ENGINEERING SCIENCE, 2011, 66 (22) :5575-5584

[4]

Ender F, 2012, 2012 18TH INTERNATIONAL WORKSHOP ON THERMAL INVESTIGATIONS OF ICS AND SYSTEMS (THERMINIC), P152

[5] CFD modelling of flow and heat transfer in the Taylor flow regime [J].

Gupta, Raghvendra ;

Fletcher, David F. ;

Haynes, Brian S. .

CHEMICAL ENGINEERING SCIENCE, 2010, 65 (06) :2094-2107

[6] Heat transfer modelling of gas-liquid slug flow without phase change in a micro tube [J].

He, Qunwu ;

Hasegawa, Yosuke ;

Kasagi, Nobuhide .

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW, 2010, 31 (01) :126-136

[7] High-sensitivity microfluidic calorimeters for biological and chemical applications [J].

Lee, Wonhee ;

Fon, Warren ;

Axelrod, Blake W. ;

Roukes, Michael L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (36) :15225-15230

[8] Chip calorimeters for the investigation of liquid phase reactions: Design rules [J].

Lerchner, J. ;

Wolf, A. ;

Wolf, G. ;

Fernandez, I. .

THERMOCHIMICA ACTA, 2006, 446 (1-2) :168-175

[9] Chip calorimetry and its use for biochemical and cell biological investigations [J].

Lerchner, Johannes ;

Maskow, Thomas ;

Wolf, Gert .

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2008, 47 (06) :991-999

[10] Enthalpy array analysis of enzymatic and binding reactions [J].

Recht, Michael I. ;

De Bruyker, Dirk ;

Bell, Alan G. ;

Wolkin, Michal V. ;

Peeters, Eric ;

Anderson, Greg B. ;

Kolatkar, Arland R. ;

Bern, Marshall W. ;

Kuhn, Peter ;

Bruce, Richard H. ;

Torres, Frank E. .

ANALYTICAL BIOCHEMISTRY, 2008, 377 (01) :33-39

← 1 2 →