The retinoblastoma protein pathway in cell cycle control and cancer

被引：220

作者：

Bartek, J ^{[1
]}

Bartkova, J ^{[1
]}

Lukas, J ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, DK-2100 Copenhagen, Denmark

来源：

EXPERIMENTAL CELL RESEARCH | 1997年 / 237卷 / 01期

关键词：

D O I：

10.1006/excr.1997.3776

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine. (C) 1997 Academic Press.

引用

页码：1 / 6

页数：6

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