Long-term shedding of infectious Epstein-Barr virus after infectious mononucleosis

被引：85
作者：
Fafi-Kremer, S
Morand, P
Brion, JP
Pavese, P
Baccard, M
Germi, R
Genoulaz, O
Nicod, S
Jolivet, M
Ruigrok, RWH
Stahl, JP
Seigneurin, JM
机构：
[1] Univ Grenoble 1, EA 2939, Lab Virol Mol & Struct, Grenoble, France
[2] Ctr Hosp Univ, Med Virol Lab, Grenoble, France
[3] Ctr Hosp Univ, Serv Malad Infect, Grenoble, France
[4] bioMerieux, Lyon, France
来源：
JOURNAL OF INFECTIOUS DISEASES | 2005年 / 191卷 / 06期
关键词：
D O I：
10.1086/428097
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epstein-Barr virus (EBV) DNA loads in peripheral blood mononuclear cells (PBMCs), plasma, and saliva, as well as infectivity of the virus in saliva, were evaluated in 20 patients for 6 months after the onset of infectious mononucleosis (IM). All patients displayed sustained high EBV DNA loads in the saliva, associated with a persistent infectivity of saliva at day 180. EBV DNA load in PBMCs decreased significantly from day 0 to day 180 ( in spite of a viral rebound between day 30 and day 90 in 90% of the patients), and EBV DNA rapidly disappeared from plasma. These data show that patients with IM remain highly infectious during convalescence.
引用
收藏
页码：985 / 989
页数：5
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