Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

被引：5

作者：

Consiglieri, Vladi Olga ^{[1
]}

Mourao, Samanta ^{[1
,2
]}

Sampaio, Mauricio ^{[1
]}

Granizo, Patricia ^{[1
]}

Garcia, Pedro ^{[1
]}

Martinello, Valeska ^{[1
]}

Spricigo, Rodrigo ^{[1
]}

Ferraz, Humberto Gomes ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Farm, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo, Brazil

[2] Univ Vale Itajai, Fac Pharm, Itajai, Brazil

来源：

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 46卷 / 01期

关键词：

Fluconazole/flowability; Tablets/dissolution; Capsules/dissolution; Plasdone; BIOEQUIVALENCE; LACTOSE; DRUG;

D O I：

10.1590/S1984-82502010000100013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies were achieved with Plasdone (R) K29/32.

引用

页码：115 / 120

页数：6

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