NF-κB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS

被引：18
作者：
Harris, Tajie H. [1 ]
Wilson, Emma H. [1 ]
Tait, Elia D. [1 ]
Buckley, Marie [1 ]
Shapira, Sagi [1 ]
Caamano, Jorge [1 ]
Artis, David [1 ]
Hunter, Christopher A. [1 ]
机构：
[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 222卷 / 1-2期
基金：
美国国家卫生研究院; 英国生物技术与生命科学研究理事会;
关键词：
Toxoplasma gondii; NF-kappa B; CD8(+) T cell; NF-KAPPA-B; INDUCIBLE NITRIC-OXIDE; ENDOGENOUS IFN-GAMMA; C-REL; IL-12; PRODUCTION; ACUTE INFECTION; CUTTING EDGE; IN-VIVO; CEREBRAL TOXOPLASMOSIS; INTRINSIC EXPRESSION;
D O I：
10.1016/j.jneuroim.2009.12.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, the role of NF-kappa B1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappa B1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-KB1(-/-) mice. Consistent with these findings. T cell transfer studies revealed that NF-kappa B1(-/-) T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-kappa B1 in T cell-mediated immunity to Toxoplasma gondii. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：19 / 28
页数：10
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