Antiviral compounds from traditional Chinese medicines Galla chinese as inhibitors of HCVNS3 protease

被引：81

作者：

Duan, DL ^{[1
]}

Li, ZQ ^{[1
]}

Luo, HP ^{[1
]}

Zhang, W ^{[1
]}

Chen, LR ^{[1
]}

Xu, XJ ^{[1
]}

机构：

[1] Peking Univ, Yangshengtang Nat Med Lab, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 24期

关键词：

Galla chinese; polyphenol; inhibitor; HCVNS3; protease;

D O I：

10.1016/j.bmcl.2004.09.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Under the guidance of bioassay, the EtOAc extract fraction of the Traditional Chinese Medicine (TCM) Galla Chinese was found to be efficient in inhibiting the NS3 protease of HCV and purified the fraction to get three polyphenol compounds 1,2,6-tri-O-galloyl-beta-D-glucose (1), 1.2,3,6-tetra-O-galloyl-beta-D-glucose (2), and 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (3), which were identified as inhibitors of Hepatitis C Virus (HCV) NS3 protease. Compounds 1, 2, and 3 inhibited HCV NS3 protease with IC50 of 1.89, 0.75, and 1.60 muM. respectively. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6041 / 6044

页数：4

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