Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

被引：61

作者：

Krishnamoorthy, Mithunah ^{[1
,2
]}

Gerhardt, Lara ^{[1
,2
]}

Maleki Vareki, Saman ^{[1
,2
,3
]}

机构：

[1] Lawson Hlth Res Inst, Canc Res Lab Program, London, ON N6A5 W9, Canada

[2] Univ Western Ontario, Dept Pathol & Lab Med, London, ON N6A 3K7, Canada

[3] Univ Western Ontario, Div Expt Oncol, Dept Oncol, London, ON N6A 3K7, Canada

来源：

CELLS | 2021年 / 10卷 / 05期

基金：

加拿大健康研究院;

关键词：

immunotherapy; MDSCs; T-cells; anti-PD-1; cancer; tumors; CD8(+) T-CELLS; ARYL-HYDROCARBON RECEPTOR; GROWTH-FACTOR-BETA; CHAIN FATTY-ACIDS; PROSTAGLANDIN E-2; DENDRITIC CELLS; TUMOR RESPONSE; MESENCHYMAL TRANSITION; HYDROGEN-PEROXIDE; ADVANCED MELANOMA;

D O I：

10.3390/cells10051170

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.

引用

页数：21

共 185 条

[41] Myeloid-derived suppressor cells as regulators of the immune system [J].

Gabrilovich, Dmitry I. ;

Nagaraj, Srinivas .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (03) :162-174

[42] TH17 cells transdifferentiate into regulatory T cells during resolution of inflammation [J].

Gagliani, Nicola ;

Vesely, Maria Carolina Amezcua ;

Iseppon, Andrea ;

Brockmann, Leonie ;

Xu, Hao ;

Palm, Noah W. ;

de Zoete, Marcel R. ;

Licona-Limon, Paula ;

Paiva, Ricardo S. ;

Ching, Travers ;

Weaver, Casey ;

Zi, Xiaoyuan ;

Pan, Xinghua ;

Fan, Rong ;

Garmire, Lana X. ;

Cotton, Matthew J. ;

Drier, Yotam ;

Bernstein, Bradley ;

Geginat, Jens ;

Stockinger, Brigitta ;

Esplugues, Enric ;

Huber, Samuel ;

Flavell, Richard A. .

NATURE, 2015, 523 (7559) :221-U225

[43] Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells [J].

Gallina, Giovanna ;

Dolcetti, Luigi ;

Serafini, Paolo ;

De Santo, Carmela ;

Marigo, Ilaria ;

Colombo, Mario P. ;

Basso, Giuseppe ;

Brombacher, Frank ;

Borrello, Ivan ;

Zanovello, Paola ;

Bicciato, Silvio ;

Bronte, Vincenzo .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (10) :2777-2790

[44] Regulation of TCR-induced IFN-γ release from islet-reactive non-obese diabetic CD8+ T cells by prostaglandin E2 receptor signaling [J].

Ganapathy, V ;

Gurlo, T ;

Jarstadmarken, HO ;

von Grafenstein, H .

INTERNATIONAL IMMUNOLOGY, 2000, 12 (06) :851-860

[45] Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab [J].

Gebhardt, Christoffer ;

Sevko, Alexandra ;

Jiang, Huanhuan ;

Lichtenberger, Ramtin ;

Reith, Maike ;

Tarnanidis, Kathrin ;

Holland-Letz, Tim ;

Umansky, Ludmila ;

Beckhove, Philipp ;

Sucker, Antje ;

Schadendorf, Dirk ;

Utikal, Jochen ;

Umansky, Viktor .

CLINICAL CANCER RESEARCH, 2015, 21 (24) :5453-5459

[46] Nitric Oxide-Producing Myeloid-Derived Suppressor Cells Inhibit Vascular E-Selectin Expression in Human Squamous Cell Carcinomas [J].

Gehad, Ahmed E. ;

Lichtman, Michael K. ;

Schmults, Chrysalyne D. ;

Teague, Jessica E. ;

Calarese, Adam W. ;

Jiang, Ying ;

Watanabe, Rei ;

Clark, Rachael A. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 (11) :2642-2651

[47] Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells [J].

Glassman, Caleb R. ;

Mathiharan, Yamuna Kalyani ;

Jude, Kevin M. ;

Su, Leon ;

Panova, Ouliana ;

Lupardus, Patrick J. ;

Spangler, Jamie B. ;

Ely, Lauren K. ;

Thomas, Christoph ;

Skiniotis, Georgios ;

Garcia, K. Christopher .

CELL, 2021, 184 (04) :983-+

[48] NKG2D ligands:: key targets of the immune response [J].

Gonzalez, Segundo ;

Lopez-Soto, Alejandro ;

Suarez-Alvarez, Beatriz ;

Lopez-Vazquez, Antonio ;

Lopez-Larrea, Carlos .

TRENDS IN IMMUNOLOGY, 2008, 29 (08) :397-403

[49] Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients [J].

Gopalakrishnan, V. ;

Spencer, C. N. ;

Nezi, L. ;

Reuben, A. ;

Andrews, M. C. ;

Karpinets, T. V. ;

Prieto, P. A. ;

Vicente, D. ;

Hoffman, K. ;

Wei, S. C. ;

Cogdill, A. P. ;

Zhao, L. ;

Hudgens, C. W. ;

Hutchinson, D. S. ;

Manzo, T. ;

de Macedo, M. Petaccia ;

Cotechini, T. ;

Kumar, T. ;

Chen, W. S. ;

Reddy, S. M. ;

Sloane, R. Szczepaniak ;

Galloway-Pena, J. ;

Jiang, H. ;

Chen, P. L. ;

Shpall, E. J. ;

Rezvani, K. ;

Alousi, A. M. ;

Chemaly, R. F. ;

Shelburne, S. ;

Vence, L. M. ;

Okhuysen, P. C. ;

Jensen, V. B. ;

Swennes, A. G. ;

McAllister, F. ;

Sanchez, E. Marcelo Riquelme ;

Zhang, Y. ;

Le Chatelier, E. ;

Zitvogel, L. ;

Pons, N. ;

Austin-Breneman, J. L. ;

Haydu, L. E. ;

Burton, E. M. ;

Gardner, J. M. ;

Sirmans, E. ;

Hu, J. ;

Lazar, A. J. ;

Tsujikawa, T. ;

Diab, A. ;

Tawbi, H. ;

Glitza, I. C. .

SCIENCE, 2018, 359 (6371) :97-103

[50] Tolerance, DCs and tryptophan: much ado about IDO [J].

Grohmann, U ;

Fallarino, F ;

Puccetti, P .

TRENDS IN IMMUNOLOGY, 2003, 24 (05) :242-248

← 1 2 3 4 5 6 7 8 9 10 →