Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

被引：61

作者：

Krishnamoorthy, Mithunah ^{[1
,2
]}

Gerhardt, Lara ^{[1
,2
]}

Maleki Vareki, Saman ^{[1
,2
,3
]}

机构：

[1] Lawson Hlth Res Inst, Canc Res Lab Program, London, ON N6A5 W9, Canada

[2] Univ Western Ontario, Dept Pathol & Lab Med, London, ON N6A 3K7, Canada

[3] Univ Western Ontario, Div Expt Oncol, Dept Oncol, London, ON N6A 3K7, Canada

来源：

CELLS | 2021年 / 10卷 / 05期

基金：

加拿大健康研究院;

关键词：

immunotherapy; MDSCs; T-cells; anti-PD-1; cancer; tumors; CD8(+) T-CELLS; ARYL-HYDROCARBON RECEPTOR; GROWTH-FACTOR-BETA; CHAIN FATTY-ACIDS; PROSTAGLANDIN E-2; DENDRITIC CELLS; TUMOR RESPONSE; MESENCHYMAL TRANSITION; HYDROGEN-PEROXIDE; ADVANCED MELANOMA;

D O I：

10.3390/cells10051170

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.

引用

页数：21

共 185 条

[1] Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis [J].

Akalay, Intissar ;

Janji, Bassam ;

Hasmim, Meriem ;

Noman, Muhammad Zaeem ;

Andre, Fabrice ;

De Cremoux, Patricia ;

Bertheau, Philippe ;

Badoual, Cecile ;

Vielh, Philippe ;

Larsen, Annette K. ;

Sabbah, Michele ;

Tan, Tuan Zea ;

Keira, Joan Herr ;

Hung, Nicole Tsang Ying ;

Thiery, Jean Paul ;

Mami-Chouaib, Fathia ;

Chouaib, Salem .

CANCER RESEARCH, 2013, 73 (08) :2418-2427

[2] Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis [J].

Alban, Tyler J. ;

Alvarado, Alvaro G. ;

Sorensen, Mia D. ;

Bayik, Defne ;

Volovetz, Josephine ;

Serbinowski, Emily ;

Mulkearns-Hubert, Erin E. ;

Sinyuk, Maksim ;

Hale, James S. ;

Onzi, Giovana R. ;

McGraw, Mary ;

Huang, Pengjing ;

Grabowski, Matthew M. ;

Wathen, Connor A. ;

Ahluwalia, Manmeet S. ;

Radivoyevitch, Tomas ;

Kornblum, Harley, I ;

Kristensen, Bjarne W. ;

Vogelbaum, Michael A. ;

Lathia, Justin D. .

JCI INSIGHT, 2018, 3 (21)

[3] Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics [J].

Alshetaiwi, Hamad ;

Pervolarakis, Nicholas ;

McIntyre, Laura Lynn ;

Ma, Dennis ;

Quy Nguyen ;

Rath, Jan Akara ;

Nee, Kevin ;

Hernandez, Grace ;

Evans, Katrina ;

Torosian, Leona ;

Silva, Anushka ;

Walsh, Craig ;

Kessenbrock, Kai .

SCIENCE IMMUNOLOGY, 2020, 5 (44)

[4]

[Anonymous], 2015, J IMMUNOTHER CANCER, DOI 10.1186/2051-1426-3-S2-P310

[5] Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections [J].

Baktash, Amoe ;

Terveer, Elisabeth M. ;

Zwittink, Romy D. ;

Hornung, Bastian V. H. ;

Corver, Jeroen ;

Kuijper, Ed J. ;

Smits, Wiep Klaas .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[6] Clinical relevance of systemic monocytic-MDSCs in patients with metastatic breast cancer [J].

Bergenfelz, Caroline ;

Roxa, Anna ;

Mehmeti, Meliha ;

Leandersson, Karin ;

Larsson, Anna-Maria .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2020, 69 (03) :435-448

[7] An experimental model of anti-PD-1 resistance exhibits activation of TGFss and Notch pathways and is sensitive to local mRNA immunotherapy [J].

Bernardo, Marie ;

Tolstykh, Tatiana ;

Zhang, Yu-an ;

Bangari, Dinesh S. ;

Cao, Hui ;

Heyl, Kerstin A. ;

Lee, Joon Sang ;

Malkova, Natalia V. ;

Malley, Katie ;

Marquez, Eladio ;

Pollard, Jack ;

Qu, Hui ;

Roberts, Errin ;

Ryan, Sue ;

Singh, Kuldeep ;

Sun, Fangxian ;

Wang, Emma ;

Bahjat, Keith ;

Wiederschain, Dmitri ;

Wagenaar, Timothy R. .

ONCOIMMUNOLOGY, 2021, 10 (01)

[8] TRANSFORMING GROWTH-FACTOR-BETA AND CYCLOSPORINE-A INHIBIT THE INDUCIBLE ACTIVITY OF THE INTERLEUKIN-2 GENE IN T-CELLS THROUGH A NONCANONICAL OCTAMER-BINDING SITE [J].

BRABLETZ, T ;

PFEUFFER, I ;

SCHORR, E ;

SIEBELT, F ;

WIRTH, T ;

SERFLING, E .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (02) :1155-1162

[9] Stat proteins and oncogenesis [J].

Bromberg, J .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) :1139-1142

[10] Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+ T cells [J].

Bronte, V ;

Apolloni, E ;

Cabrelle, A ;

Ronca, R ;

Serafini, P ;

Zamboni, P ;

Restifo, NP ;

Zanovello, P .

BLOOD, 2000, 96 (12) :3838-3846

← 1 2 3 4 5 6 7 8 9 10 →