The diagnostic role of Procalcitonin and other biomarkers in discriminating infectious from non-infectious fever

被引：250
作者：
Limper, M. [1 ,2 ]
de Kruif, M. D. [1 ]
Duits, A. J. [2 ]
Brandjes, D. P. M. [1 ]
van Gorp, E. C. M. [1 ,3 ]
机构：
[1] Slotervaart Hosp, Dept Internal Med, NL-1066 EC Amsterdam, Netherlands
[2] Red Cross Blood Bank Fdn, Immunol Lab Dept, Willemstad, Curacao, Neth Antilles
[3] Erasmus MC, Dept Virol, Rotterdam, Netherlands
来源：
JOURNAL OF INFECTION | 2010年 / 60卷 / 06期
关键词：
Fever; Biological markers; Autoimmune diseases; C-reactive protein; Procalcitonin; C-REACTIVE PROTEIN; FAMILIAL-MEDITERRANEAN-FEVER; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYOCARDIAL-INFARCTION; INFLAMMATORY-BOWEL-DISEASE; TUMOR-NECROSIS-FACTOR; ACUTE-PHASE RESPONSE; SERUM PROCALCITONIN; BACTERIAL-INFECTION; PULMONARY-EMBOLISM;
D O I：
10.1016/j.jinf.2010.03.016
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Fever is not only observed in the course of a bacterial or viral infection, but can be a symptom of, for instance, auto-immune, malignant or thromboembolic disease. Determining the etiology of fever in a fast and reliable way is of pivotal importance, as different causes of fever may ask for different therapies. Neither clinical signs and symptoms, nor traditional biomarkers, such as CRP, leukocytes and ESR have sufficient sensitivity and specificity to guide treatment decisions. In this review we focus on the value of traditional and newer biomarkers in non-infectious febrile diseases. Procalcitonin (PCT) seems to be the most helpful laboratory marker for the differentiation of causes of fever, particularly in autoimmune, autoinflammatory and malignant diseases. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：409 / 416
页数：8
相关论文
共 70 条
  • [1] Serum interleukin-6, procalcitonin and C-reactive protein levels in subjects with active Behcet's disease
    Adam, B
    Calikoglu, E
    [J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2004, 18 (03) : 318 - 320
  • [2] Glyco-biomarkers: Potential determinants of cellular physiology and pathology
    Alavi, Azita
    Axford, John S.
    [J]. DISEASE MARKERS, 2008, 25 (4-5) : 193 - 205
  • [3] Excess hospitalisation burden associated with Clostridium difficile in patients with inflammatory bowel disease
    Ananthakrishnan, A. N.
    McGinley, E. L.
    Binion, D. G.
    [J]. GUT, 2008, 57 (02) : 205 - 210
  • [4] HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION
    ASSICOT, M
    GENDREL, D
    CARSIN, H
    RAYMOND, J
    GUILBAUD, J
    BOHUON, C
    [J]. LANCET, 1993, 341 (8844) : 515 - 518
  • [5] Pyocalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations
    Becker, Kenneth L.
    Snider, Richard
    Nylen, Eric S.
    [J]. CRITICAL CARE MEDICINE, 2008, 36 (03) : 941 - 952
  • [6] Body temperature - A marker of infarct size in the era of early reperfusion
    Ben-Dor, I
    Haim, M
    Rechavia, E
    Murininkas, D
    Nahon, M
    Harell, D
    Porter, A
    Iakobishvili, Z
    Scapa, E
    Battler, A
    Hasdai, D
    [J]. CARDIOLOGY, 2005, 103 (04) : 169 - 173
  • [7] A prospective multicenter study on fever of unknown origin - The yield of a structured diagnostic protocol
    Bleeker-Rovers, Chantal P.
    Vos, Fidel J.
    de Kleijn, Elisabeth M. H. A.
    Mudde, Aart H.
    Dofferhoff, Ton S. M.
    Richter, Clemens
    Smilde, Tineke J.
    Krabbe, Paul F. M.
    Oyen, Wim J. G.
    van der Meer, Jos W. M.
    [J]. MEDICINE, 2007, 86 (01) : 26 - 38
  • [8] INFECTIOUS COMPLICATIONS OF CYCLOPHOSPHAMIDE TREATMENT FOR VASCULITIS
    BRADLEY, JD
    BRANDT, KD
    KATZ, BP
    [J]. ARTHRITIS AND RHEUMATISM, 1989, 32 (01): : 45 - 53
  • [9] Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Briel, Matthias
    Schuetz, Philipp
    Mueller, Beat
    Young, Jim
    Schild, Ursula
    Nusbaumer, Charly
    Periat, Pierre
    Bucher, Heiner C.
    Christ-Crain, Mirjam
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (18) : 2000 - 2007
  • [10] Procalcitonin for discrimination between activity of systemic autoimmune disease and systemic bacterial infection
    Brunkhorst, R
    Eberhardt, OK
    Haubitz, M
    Brunkhorst, FM
    [J]. INTENSIVE CARE MEDICINE, 2000, 26 : S199 - S201
1234567