Alterations in lipid composition and neuronal injury in primates following chronic aluminium exposure

被引：41

作者：

Sarin, S ^{[1
]}

Gupta, V ^{[1
]}

Gill, KD ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Biochem, Chandigarh 160014, India

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1997年 / 59卷 / 1-3期

关键词：

aluminium; brain; lipids; membrane; monkey;

D O I：

10.1007/BF02783238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of chronic aluminium exposure (25 mg/kg b.wt.) was studied on the lipid composition and various membrane-bound enzymes in different regions of monkey brain. aluminium (Al) administration caused a significant decrease in the total lipid, glycolipid, and phospholipid content of primate brain. Cholesterol levels and the phospholipid to cholesterol ratio were, however, markedly increased as a consequence of Al administration, thereby indicating a loss of membrane integrity. This was further confirmed when Al treatment was found to have a significant effect on the various membrane-bound enzymes in terms of decreased activities of Na+ K+ ATPase and acetylcholinesterase, along with a decrease in the activity of the myelin-specific enzyme, 2'3'-cyclic nucleotide phosphohydrolase.

引用

页码：133 / 143

页数：11

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