The lipid-binding side of Notch ligands

被引：2
作者：
Shilo, Ben-Zion [1 ]
Sprinzak, David [2 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel
[2] Tel Aviv Univ, Dept Biochem & Mol Biol, George S Wise Fac Life Sci, Tel Aviv, Israel
来源：
EMBO JOURNAL | 2017年 / 36卷 / 15期
关键词：
FORCE;
D O I：
10.15252/embj.201797621
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journal, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch binding and activation, thus proposing a new mode of Notch activity regulation.
引用
收藏
页码：2182 / 2183
页数：2
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