The lipid-binding side of Notch ligands

被引：2
|
作者：
Shilo, Ben-Zion [1 ]
Sprinzak, David [2 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel
[2] Tel Aviv Univ, Dept Biochem & Mol Biol, George S Wise Fac Life Sci, Tel Aviv, Israel
来源：
EMBO JOURNAL | 2017年 / 36卷 / 15期
关键词：
FORCE;
D O I：
10.15252/embj.201797621
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journal, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch binding and activation, thus proposing a new mode of Notch activity regulation.
引用
收藏
页码：2182 / 2183
页数：2
相关论文
共 50 条
  • [1] Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
    Chillakuri, Chandramouli R.
    Sheppard, Devon
    Ilagan, Ma. Xenia G.
    Holt, Laurie R.
    Abbott, Felicity
    Liang, Shaoyan
    Kopan, Raphael
    Handford, Penny A.
    Lea, Susan M.
    CELL REPORTS, 2013, 5 (04): : 861 - 867
  • [2] Lipid-binding proteins: Structure of the phospholipid ligands
    Marsh, D
    PROTEIN SCIENCE, 2003, 12 (09) : 2109 - 2117
  • [3] Interactions between plant lipid-binding proteins and their ligands
    Guo, Ze-Hua
    Lung, Shiu-Cheung
    Hamdan, Mohd Fadhli
    Chye, Mee-Len
    PROGRESS IN LIPID RESEARCH, 2022, 86
  • [4] LIPID-BINDING PROTEINS IN PLANTS
    KADER, JC
    CHEMISTRY AND PHYSICS OF LIPIDS, 1985, 38 (1-2) : 51 - 62
  • [5] A map of the lipid-binding proteome
    Nature Methods, 2015, 12 (8) : 708 - 708
  • [6] INTESTINAL LIPID-BINDING PROTEIN
    SZIEGOLEIT, A
    BHAKDI, S
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1979, 360 (09): : 1197 - 1197
  • [7] DESIGN OF LIPID-BINDING PEPTIDES
    KAISER, ET
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1982, 184 (SEP): : 85 - BIOL
  • [8] Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    Anthony, TE
    Mason, HA
    Gridley, T
    Fishell, G
    Heintz, N
    GENES & DEVELOPMENT, 2005, 19 (09) : 1028 - 1033
  • [9] Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
    Suckling, Richard J.
    Korona, Boguslawa
    Whiteman, Pat
    Chillakuri, Chandramouli
    Holt, Laurie
    Handford, Penny A.
    Lea, Susan M.
    EMBO JOURNAL, 2017, 36 (15): : 2204 - 2215
  • [10] LIPID-BINDING AT LOW WORK LEVELS
    WOOD, PS
    DANIELS, NWR
    GREENSHEILDS, RN
    JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 1974, 25 (07) : 886 - 886
12345