Luminescent Nanoparticles with Lanthanide-Containing Poly(ethylene glycol) Poly(ε-caprolactone) Block Copolymers

被引：16

作者：

Thevenaz, David C. ^{[1
]}

Monnier, Christophe A. ^{[1
]}

Balog, Sandor ^{[1
]}

Fiore, Gina L. ^{[1
]}

机构：

[1] Univ Fribourg, Adolphe Merkle Inst, CH-1700 Fribourg, Switzerland

来源：

BIOMACROMOLECULES | 2014年 / 15卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

COACERVATE CORE MICELLES; METAL; COMPLEX; POLYMERS; WATER; CRYSTALLIZATION; MORPHOLOGY; BIPYRIDINE; TRIBLOCK; IONS;

D O I：

10.1021/bm501058n

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lanthanide-containing nanoparticles have attracted much attention due to their unique optical properties and potential in nanotechnological applications. An amphiphilic block copolymer of poly(ethylene glycol)-b-poly(epsilon-caprolactone) methyl ether (mPEG-PCL) was functionalized with a dipicolinic acid (dpa) moiety and coordinated to lanthanide ions to afford [Ln(dpa-PCL-PEG-OCH3)(3)]-(HNEt3)(3) (Ln = Eu3+, Tb3+). Micelle-like nanoparticles of dpa-PCL-PEG-OCH3 macroligand and metal-centered polymers were prepared by solvent displacement methods. Dynamic light scattering analysis (DLS) and cryogenic transmission electron microscopy images confirmed the presence of solid sphere (<47 nm in diameter) and vesicle (>47 nm in diameter) morphologies. The viability and stability of the lanthanide complexes in micelle-like nanoparticles was explored by DLS and luminescence spectroscopy, and found to be stable for several weeks.

引用

页码：3994 / 4001

页数：8

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