Associations of Antimicrobial-Resistant Gram-Negative Bloodstream Infections with Outcomes among Hospitalized Pediatric Patients in the United States

被引：0

作者：

Spaulding, Alicen Burns ^{[1
]}

Watson, David ^{[1
]}

Dreyfus, Jill ^{[2
]}

Heaton, Phillip ^{[3
]}

Koutsari, Christina ^{[4
]}

Kharbanda, Anupam B. ^{[5
]}

机构：

[1] Childrens Minnesota Res Inst, 2525 Chicago Ave S,MS 40-460, Minneapolis, MN 55404 USA

[2] Premier Inc, Charlotte, NC USA

[3] Childrens Minnesota, Minneapolis, MN USA

[4] Childrens Minnesota, Antimicrobial Stewardship Program, Minneapolis, MN USA

[5] Childrens Minnesota, Pediat Emergency Med, Crit Care Serv, Minneapolis, MN USA

来源：

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES | 2021年 / 16卷 / 06期

关键词：

antimicrobial resistance; bloodstream infections; pediatric; RISK-FACTORS; ENTEROBACTERIACEAE; CHILDREN; SUSCEPTIBILITY; ORGANISMS; TRENDS;

D O I：

10.1055/s-0041-1731643

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective The aim of this study was to assess the impact of pediatric antimicrobial-resistant gram-negative bloodstream infections (GNBSIs). Methods A retrospective cohort study (2009-2016) was conducted using the Premier Healthcare Database among pediatric admissions with GNBSIs at hospitals reporting microbiology data. Infections for neonates and nonneonates were classified as multidrug resistance (MDR), resistant to one or two antibiotic drug classes (1-2DR), or susceptible. Results Among 1,276 GNBSIs, 266 (20.8%) infections were 1-2DR and 23 (1.8%) MDR. Compared with susceptible GNBSIs, MDR nonneonates had higher mortality and higher costs, whereas 1-2DR neonates had longer stays and higher costs. Conclusions Antimicrobial-resistant GNBSIs were associated with worse outcomes among pediatric hospitalized patients.

引用

页码：247 / 254

页数：8

共 50 条

[21] Inappropriate initial antimicrobial therapy for hematological malignancies patients with Gram-negative bloodstream infections [J].

Tang, Yishu ;

Wu, Xinyu ;

Cheng, Qian ;

Li, Xin .

INFECTION, 2020, 48 (01) :109-116

[22] Efficacy and appropriateness of novel antibiotics in response to antimicrobial-resistant gram-negative bacteria in patients with sepsis in the ICU [J].

Garduno, Alexis ;

Martin-Loeches, Ignacio .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2022, 20 (04) :513-531

[23] Optimal duration of antimicrobial therapy for uncomplicated Gram-negative bloodstream infections [J].

Nelson, Avery N. ;

Justo, Julie Ann ;

Bookstaver, P. Brandon ;

Kohn, Joseph ;

Albrecht, Helmut ;

Al-Hasan, Majdi N. .

INFECTION, 2017, 45 (05) :613-620

[24] Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant Gram-negative bacteria among intensive care unit patients [J].

Warren, DK ;

Hill, HA ;

Merz, LR ;

Kollef, MH ;

Hayden, MK ;

Fraser, VJ ;

Fridkin, SK .

CRITICAL CARE MEDICINE, 2004, 32 (12) :2450-2456

[25] A Narrative Review of Healthcare-Associated Gram-Negative Infections Among Pediatric Patients in Middle Eastern Countries [J].

Al Dabbagh, Mona ;

Alghounaim, Mohammad ;

Almaghrabi, Rana H. ;

Dbaibo, Ghassan ;

Ghatasheh, Ghassan ;

Ibrahim, Hanan M. ;

Aziz, Mohamed Abdel ;

Hassanien, Ashraf ;

Mohamed, Naglaa .

INFECTIOUS DISEASES AND THERAPY, 2023, 12 (05) :1217-1235

[26] Epidemiology of Gram-Negative Bloodstream Infections in the United States: Results From a Cohort of 24 Hospitals [J].

Ince, Dilek ;

Fiawoo, Suiyini ;

Choudhury, Rebecca ;

Cosgrove, Sara E. ;

Dobrzynski, David ;

Gold, Howard ;

Lee, Jae Hyoung ;

Percival, Kelly M. ;

Shulder, Stephanie ;

Sony, Deepthi ;

Spivak, Emily S. ;

Tamma, Pranita D. ;

Nori, Priya .

OPEN FORUM INFECTIOUS DISEASES, 2023, 10 (07)

[27] Multidrug-resistant Gram-negative Bacterial Bloodstream Infections in Children's Hospitals in Japan, 2010-2017 [J].

Aizawa, Yuta ;

Shoji, Takayo ;

Ito, Kenta ;

Kasai, Masashi ;

Sakurai, Hiroki ;

Toyofuku, Etsushi ;

Minami, Kisei ;

Hoshino, Tadashi ;

Horikoshi, Yuho .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2019, 38 (07) :653-659

[28] Gram-negative bloodstream infections in hemodialysis patients: A retrospective study [J].

Shimon, Orit ;

Green, Hefziba ;

Eliakim-Raz, Noa ;

Rozen-Zvi, Benaya ;

Ben-Zvi, Haim ;

Zohar, Iris ;

Bishara, Jihad ;

Yahav, Dafna .

CLINICAL NEPHROLOGY, 2018, 90 (02) :117-124

[29] Risk Factors of Bloodstream Infections Caused by Carbapenem-resistant Gram-negative Pathogens in Pediatric Critical Care Settings [J].

Bal, Zumrut Sahbudak ;

Duyu, Muhterem ;

Kamit, Fulya ;

Yazici, Pinar ;

Anil, Ayse Berna ;

Ciftdogan, Dilek Yilmaz ;

Ozkalay, Nisei Yilmaz ;

Cilli, Feriha ;

Karapinar, Bulent .

JOURNAL OF PEDIATRIC RESEARCH, 2019, 6 (03) :180-185

[30] Antibiotic-resistant Gram-negative Bacteremia in Pediatric Oncology Patients-Risk Factors and Outcomes [J].

Haeusler, Gabrielle M. ;

Mechinaud, Francoise ;

Daley, Andrew J. ;

Starr, Mike ;

Shann, Frank ;

Connell, Thomas G. ;

Bryant, Penelope A. ;

Donath, Susan ;

Curtis, Nigel .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2013, 32 (07) :723-726

← 1 2 3 4 5 →