Associations of Antimicrobial-Resistant Gram-Negative Bloodstream Infections with Outcomes among Hospitalized Pediatric Patients in the United States

被引：0
|
作者：
Spaulding, Alicen Burns [1 ]
Watson, David [1 ]
Dreyfus, Jill [2 ]
Heaton, Phillip [3 ]
Koutsari, Christina [4 ]
Kharbanda, Anupam B. [5 ]
机构：
[1] Childrens Minnesota Res Inst, 2525 Chicago Ave S,MS 40-460, Minneapolis, MN 55404 USA
[2] Premier Inc, Charlotte, NC USA
[3] Childrens Minnesota, Minneapolis, MN USA
[4] Childrens Minnesota, Antimicrobial Stewardship Program, Minneapolis, MN USA
[5] Childrens Minnesota, Pediat Emergency Med, Crit Care Serv, Minneapolis, MN USA
来源：
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES | 2021年 / 16卷 / 06期
关键词：
antimicrobial resistance; bloodstream infections; pediatric; RISK-FACTORS; ENTEROBACTERIACEAE; CHILDREN; SUSCEPTIBILITY; ORGANISMS; TRENDS;
D O I：
10.1055/s-0041-1731643
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objective The aim of this study was to assess the impact of pediatric antimicrobial-resistant gram-negative bloodstream infections (GNBSIs). Methods A retrospective cohort study (2009-2016) was conducted using the Premier Healthcare Database among pediatric admissions with GNBSIs at hospitals reporting microbiology data. Infections for neonates and nonneonates were classified as multidrug resistance (MDR), resistant to one or two antibiotic drug classes (1-2DR), or susceptible. Results Among 1,276 GNBSIs, 266 (20.8%) infections were 1-2DR and 23 (1.8%) MDR. Compared with susceptible GNBSIs, MDR nonneonates had higher mortality and higher costs, whereas 1-2DR neonates had longer stays and higher costs. Conclusions Antimicrobial-resistant GNBSIs were associated with worse outcomes among pediatric hospitalized patients.
引用
收藏
页码：247 / 254
页数：8
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