Hepatectomy and immune checkpoint inhibitor treatment for liver metastasis originating from non-cutaneous melanoma: a report of three cases

被引：2

作者：

Asahi, Yoh ^{[1
]}

Kamiyama, Toshiya ^{[1
]}

Kakisaka, Tatshiko ^{[1
]}

Orimo, Tatsuya ^{[1
]}

Shimada, Shingo ^{[1
]}

Nagatsu, Akihisa ^{[1
]}

Sakamoto, Yuzuru ^{[1
]}

Ishikawa, Takaya ^{[1
]}

Kamachi, Hirofumi ^{[1
]}

Mitsuhashi, Tomoko ^{[2
]}

Takeuchi, Satoshi ^{[3
,4
]}

Dosaka-Akita, Hirotoshi ^{[3
,4
]}

Taketomi, Akinobu ^{[1
]}

机构：

[1] Hokkaido Univ Hosp, Dept Gastroenterol Surg 1, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ Hosp, Dept Surg Pathol, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan

[3] Hokkaido Univ, Dept Med Oncol, Fac Med, Grad Sch Med,Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan

[4] Hokkaido Univ, Grad Sch Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan

来源：

INTERNATIONAL CANCER CONFERENCE JOURNAL | 2021年 / 10卷 / 04期

关键词：

Melanoma; Hepatectomy; Liver metastasis; Immune checkpoint inhibitor; DOUBLE-BLIND; FOLLOW-UP; IPILIMUMAB; RESECTION; PHASE-3; VEMURAFENIB; MANAGEMENT; NIVOLUMAB; SAFETY;

D O I：

10.1007/s13691-021-00495-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The outcomes of hepatectomy alone for liver metastasis derived from non-cutaneous melanoma are insufficient, and the outcomes of systemic therapy alone are also insufficient, even since the development of immune checkpoint inhibitors (ICIs). We report the cases of three patients, in whom liver metastasis derived from non-cutaneous melanoma was treated with hepatectomy combined with ICI therapy, which was administered in various settings. One patient received ICI treatment for recurrent melanoma and survived 107 months after the first hepatectomy, one patient received both preoperative and adjuvant ICI treatment and has been disease-free for 27 months, and another patient received postoperative ICI treatment after reduction hepatectomy and has been alive with disease for 47 months. Since long-term survival is possible, hepatectomy combined with ICI therapy should be considered for the treatment of liver metastasis derived from non-cutaneous melanoma.

引用

页码：274 / 279

页数：6

共 26 条

[1] The surgical management of metastatic melanoma [J].

Allen, PJ ;

Coit, DG .

ANNALS OF SURGICAL ONCOLOGY, 2002, 9 (08) :762-770

[2] Primary hepatic melanoma A case report of computed tomography and magnetic resonance imaging findings [J].

Ao, Weiqun ;

Wang, Jian ;

Mao, Guoqun ;

Yang, Guangzhao ;

Han, Xiaoyu ;

Jia, Yuzhu ;

Cheng, Yougen .

MEDICINE, 2019, 98 (25) :e16165

[3] Adjuvant nivolumab versus ipilimumab in resected stage IIIB-C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial [J].

Ascierto, Paolo A. ;

Del Vecchio, Michele ;

Mandala, Mario ;

Gogas, Helen ;

Arance, Ana M. ;

Dalle, Stephane ;

Cowey, C. Lance ;

Schenker, Michael ;

Grob, Jean-Jacques ;

Chiarion-Sileni, Vanna ;

Marquez-Rodas, Ivan ;

Butler, Marcus O. ;

Maio, Michele ;

Middleton, Mark R. ;

de la Cruz-Merino, Luis ;

Arenberger, Petr ;

Atkinson, Victoria ;

Hill, Andrew ;

Fecher, Leslie A. ;

Millward, Michael ;

Khushalani, Nikhil, I ;

Queirolo, Paola ;

Lobo, Maurice ;

de Pril, Veerle ;

Loffredo, John ;

Larkin, James ;

Weber, Jeffrey .

LANCET ONCOLOGY, 2020, 21 (11) :1465-1477

[4] Systematic review and meta-analysis of liver resection for metastatic melanoma [J].

Aubin, J. -M. ;

Rekman, J. ;

Vandenbroucke-Menu, F. ;

Lapointe, R. ;

Fairfull-Smith, R. J. ;

Mimeault, R. ;

Balaa, F. K. ;

Martel, G. .

BRITISH JOURNAL OF SURGERY, 2013, 100 (09) :1138-1147

[5] Safety and Feasibility of Lung Resection After Immunotherapy for Metastatic or Unresectable Tumors [J].

Bott, Matthew J. ;

Cools-Lartigue, Jonathan ;

Tan, Kay See ;

Dycoco, Joseph ;

Bains, Manjit S. ;

Downey, Robert J. ;

Huang, James ;

Isbell, James M. ;

Molena, Daniela ;

Park, Bernard J. ;

Rusch, Valerie W. ;

Sihag, Smita ;

Jones, David R. ;

Adusumilli, Prasad S. .

ANNALS OF THORACIC SURGERY, 2018, 106 (01) :178-183

[6]

Chang AE, 1998, CANCER, V83, P1664, DOI 10.1002/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO

[7]

2-G

[8] Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].

Chapman, Paul B. ;

Hauschild, Axel ;

Robert, Caroline ;

Haanen, John B. ;

Ascierto, Paolo ;

Larkin, James ;

Dummer, Reinhard ;

Garbe, Claus ;

Testori, Alessandro ;

Maio, Michele ;

Hogg, David ;

Lorigan, Paul ;

Lebbe, Celeste ;

Jouary, Thomas ;

Schadendorf, Dirk ;

Ribas, Antoni ;

O'Day, Steven J. ;

Sosman, Jeffrey A. ;

Kirkwood, John M. ;

Eggermont, Alexander M. M. ;

Dreno, Brigitte ;

Nolop, Keith ;

Li, Jiang ;

Nelson, Betty ;

Hou, Jeannie ;

Lee, Richard J. ;

Flaherty, Keith T. ;

McArthur, Grant A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516

[9] Noncutaneous Melanomas: A Single-Center Analysis [J].

Del Prete, Valerio ;

Chaloupka, Karla ;

Holzmann, David ;

Fink, Daniel ;

Levesque, Mitchell ;

Dummer, Reinhard ;

Goldinger, Simone M. .

DERMATOLOGY, 2016, 232 (01) :22-29

[10] Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial [J].

Eggermont, Alexander M. M. ;

Blank, Christian U. ;

Mandala, Mario ;

Long, Georgina V. ;

Atkinson, Victoria G. ;

Dalle, Stephane ;

Haydon, Andrew M. ;

Meshcheryakov, Andrey ;

Khattak, Adnan ;

Carlino, Matteo S. ;

Sandhu, Shahneen ;

Larkin, James ;

Puig, Susana ;

Ascierto, Paolo A. ;

Rutkowski, Piotr ;

Schadendorf, Dirk ;

Koornstra, Rutger ;

Hernandez-Aya, Leonel ;

Di Giacomo, Anna Maria ;

van den Eertwegh, Alfonsus J. M. ;

Grob, Jean-Jacques ;

Gutzmer, Ralf ;

Jamal, Rahima ;

Lorigan, Paul C. ;

van Akkooi, Alexander C. J. ;

Krepler, Clemens ;

Ibrahim, Nageatte ;

Marreaud, Sandrine ;

Kicinski, Michal ;

Suciu, Stefan ;

Robert, Caroline .

JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (33)

← 1 2 3 →