Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland

被引：6
作者：
Patel, R. S.
Hughes, C. W.
Fredericks, S.
Lee, C. S.
Rose, B.
Gao, K.
Smith, G.
Hong, A.
O'Brien, C. J.
机构：
[1] Sydney Canc Ctr, Sydney Head & Neck Canc Inst, Sydney, NSW 2050, Australia
[2] Univ Sydney, Royal Prince Alfred Hosp, Dept Anat Pathol, Sydney, NSW 2006, Australia
[3] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia
[4] Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2006, Australia
[5] Sydney Canc Ctr, Dept Radiat Oncol, Sydney, NSW, Australia
来源：
HISTOPATHOLOGY | 2007年 / 51卷 / 01期
关键词：
carcinoma expleomorphic adenoma; cyclin A; immunohistochemistry; pleomorphic adenoma; salivary gland tumour;
D O I：
10.1111/j.1365-2559.2007.02729.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.
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页码：21 / 25
页数：5
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