Life or death: disease-tolerant coral species activate autophagy following immune challenge

被引:56
作者
Fuess, Lauren E. [1 ]
Pinzon, Jorge H. C. [1 ,3 ]
Weil, Ernesto [2 ]
Grinshpon, Robert D. [1 ]
Mydlarz, Laura D. [1 ]
机构
[1] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA
[2] Univ Puerto Rico, Dept Marine Sci, Mayaguez, PR 00709 USA
[3] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA
关键词
coral; cell death; climate change; immunity; apoptosis; autophagy; CLIMATE-CHANGE; CELL-DEATH; NUTRIENT ENRICHMENT; STRESS; REEF; APOPTOSIS; WINNERS; RESILIENCE; RESPONSES; IMPACTS;
D O I
10.1098/rspb.2017.0771
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species. Disease-susceptible species Orbicella faveolata activated pathways associated with apoptosis. By contrast, disease-tolerant species Porites porites and Porites astreoides activated autophagic pathways. Moderately susceptible species Pseudodiploria strigosa activated a mixture of these pathways. These findings were corroborated by apoptotic caspase protein assays, which indicated increased caspase activity following immune stimulation in susceptible species. Our results indicate that in response to immune stress, disease-tolerant species activate cellular adaptive mechanisms such as autophagy, while susceptible species turn on cell death pathways. Differences in these cellular maintenance pathways may therefore influence the organismal stress response. Further study of these pathways will increase understanding of differential stress response and species survival in the face of changing environments.
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页数:9
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共 89 条
[11]   Autophagy as a defense strategy against stress: focus on Paracentrotus lividus sea urchin embryos exposed to cadmium [J].
Chiarelli, Roberto ;
Martino, Chiara ;
Agnello, Maria ;
Bosco, Liana ;
Roccheri, Maria Carmela .
CELL STRESS & CHAPERONES, 2016, 21 (01) :19-27
[12]   Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction [J].
Chow, JC ;
Young, DW ;
Golenbock, DT ;
Christ, WJ ;
Gusovsky, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10689-10692
[13]   NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation [J].
Cooney, Rachel ;
Baker, John ;
Brain, Oliver ;
Danis, Benedicte ;
Pichulik, Tica ;
Allan, Philip ;
Ferguson, David J. P. ;
Campbell, Barry J. ;
Jewell, Derek ;
Simmons, Alison .
NATURE MEDICINE, 2010, 16 (01) :90-U128
[14]   Anthropogenic environmental change and the emergence of infectious diseases in wildlife [J].
Daszak, P ;
Cunningham, AA ;
Hyatt, AD .
ACTA TROPICA, 2001, 78 (02) :103-116
[15]   The 27-year decline of coral cover on the Great Barrier Reef and its causes [J].
De'ath, Glenn ;
Fabricius, Katharina E. ;
Sweatman, Hugh ;
Puotinen, Marji .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (44) :17995-17999
[16]   Water quality as a regional driver of coral biodiversity and macroalgae on the Great Barrier Reef [J].
De'ath, Glenn ;
Fabricius, Katharina .
ECOLOGICAL APPLICATIONS, 2010, 20 (03) :840-850
[17]   Toll-like receptors control autophagy [J].
Delgado, Monica A. ;
Elmaoued, Rasha A. ;
Davis, Alexander S. ;
Kyei, George ;
Deretic, Vojo .
EMBO JOURNAL, 2008, 27 (07) :1110-1121
[18]   Autophagy, Immunity, and Microbial Adaptations [J].
Deretic, Vojo ;
Levine, Beth .
CELL HOST & MICROBE, 2009, 5 (06) :527-549
[19]   Climate-change winners and losers: stream macroinvertebrates of a submontane region in Central Europe [J].
Domisch, Sami ;
Jaehnig, Sonja C. ;
Haase, Peter .
FRESHWATER BIOLOGY, 2011, 56 (10) :2009-2020
[20]   Reef degradation and coral biodiversity in Indonesia: Effects of land-based pollution, destructive fishing practices and changes over time [J].
Edinger, EN ;
Jompa, J ;
Limmon, GV ;
Widjatmoko, W ;
Risk, MJ .
MARINE POLLUTION BULLETIN, 1998, 36 (08) :617-630