Antimycobacterial activity of lichen metabolites in vitro

被引：151

作者：

Ingolfsdottir, K

Chung, GAC

Skulason, VG

Gissurarson, SR

Vilhelmsdottir, M

机构：

[1] Univ Iceland, Dept Pharm, IS-107 Reykjavik, Iceland

[2] Glaxo Wellcome Res & Dev Ltd, Stevenage SG1 2NY, Herts, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 1998年 / 6卷 / 02期

关键词：

lichen; antimycobacterial; usnic acid; lobaric acid; atranorin; protolichesterinic acid; salazinic acid;

D O I：

10.1016/S0928-0987(97)00078-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC value of 33 mu g/ml. Atranorin and lobaric acid, both isolated from Stereocaulon alpinum, salazinic acid from Parmelia saxatilis and protolichesterinic acid from Cetraria islandica all showed MIC values greater than or equal to 125 mu g/ml. (C) 1998 Elsevier Science B.V.

引用

页码：141 / 144

页数：4